INT260422

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.58
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EGF) extracellular space (EGF) extracellular region (EGF)
plasma membrane (EGF)
EGF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 82 93.52 High High
cytokine 111 92.48 High High
chemokine 21 54.24 Quite High
fibrosis 1 38.84 Quite Low
metalloproteinase 102 5.00 Very Low Very Low Very Low
COX-2 inhibitor 23 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
cINOD 8 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 112 97.76 Very High Very High Very High
INFLAMMATION 93 93.52 High High
Herpes Simplex Virus 238 88.64 High High
Injury 37 73.80 Quite High
Sarcoma 79 50.00 Quite Low
Malignant Neoplastic Disease 4 39.48 Quite Low
Fibrosis 1 38.84 Quite Low
Adhesions 43 35.12 Quite Low
Cancer 25 5.00 Very Low Very Low Very Low
Disease 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endogenous levels of EGF were high as the supernatants obtained from uninfected cells also showed higher levels of EGF secreted (data not shown).


Positive_regulation (levels) of Localization (secreted) of EGF
1) Confidence 0.10 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 1.11 Pain Relevance 0.35
However, a laboratory analysis of human PRP samples demonstrated increased concentrations of PDGF, TGFbeta, VEGF, and EGF, while not showing an increase in IGF-1 [25].
Positive_regulation (increased) of Localization (concentrations) of EGF
2) Confidence 0.05 Published 2008 Journal Curr Rev Musculoskelet Med Section Body Doc Link PMC2682411 Disease Relevance 0.22 Pain Relevance 0.05
Using the MTS assay, it was found that there was no toxic effect of URG and RG with increasing concentration up to 1,000 ?
Positive_regulation (increasing) of Neg (no) Localization (effect) of URG
3) Confidence 0.04 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635732 Disease Relevance 0.25 Pain Relevance 0.17

General Comments

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