INT260424

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 8.19
Pain Relevance 2.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tlr9) signal transduction (Tlr9) endoplasmic reticulum (Tlr9)
plasma membrane (Tlr9) intracellular (Tlr9) lysosome (Tlr9)
Anatomy Link Frequency
macrophages 1
poly 1
B cells 1
neutrophil 1
Tlr9 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 11 99.68 Very High Very High Very High
Morphine 120 99.60 Very High Very High Very High
Inflammation 70 98.96 Very High Very High Very High
cytokine 96 98.44 Very High Very High Very High
ischemia 10 94.96 High High
Opioid 36 87.68 High High
rheumatoid arthritis 51 83.96 Quite High
fibrosis 6 80.56 Quite High
agonist 26 61.92 Quite High
Paracetamol 6 47.08 Quite Low
Disease Link Frequency Relevance Heat
Aging 10 99.52 Very High Very High Very High
INFLAMMATION 81 99.28 Very High Very High Very High
Infection 167 99.00 Very High Very High Very High
Mycobacterial Infection 141 98.96 Very High Very High Very High
Apoptosis 104 98.76 Very High Very High Very High
Cv Unclassified Under Development 10 94.96 High High
Reperfusion Injury 7 94.60 High High
Cytomegalovirus Infection 4 94.12 High High
Severe Combined Immunodeficiency 2 90.96 High High
Autoimmune Disease 39 89.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, we found that inhibition of TLR9 prevents morphine and M. tuberculosis -induced apoptosis through pro-apoptotic and anti-apoptotic pathways.
Negative_regulation (inhibition) of TLR9 associated with mycobacterial infection, apoptosis and morphine
1) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824811 Disease Relevance 2.06 Pain Relevance 0.77
Notably, a deficiency in TLR9 mice is resistant to this additive effect.
Negative_regulation (deficiency) of TLR9
2) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824811 Disease Relevance 1.99 Pain Relevance 1.09
As evidence that the inflammasome response operates independently of other known DNA-sensing mechanisms, it was shown that, following exposure to adenovirus DNA, caspase-1 processing was intact in macrophages that lack both TLR9 and the TLR adaptor protein MyD88.
Negative_regulation (lack) of TLR9 in macrophages
3) Confidence 0.28 Published 2010 Journal Autoimmune Diseases Section Body Doc Link PMC2989704 Disease Relevance 0.15 Pain Relevance 0
Inhibition of both TLR9 and HMGB1 caused maximal inflammatory cytokine suppression in neutrophil cultures and conferred even greater protection from ischemia-reperfusion injury in vivo [13].
Negative_regulation (Inhibition) of TLR9 in neutrophil associated with reperfusion injury, inflammation, ischemia and cytokine
4) Confidence 0.24 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2939438 Disease Relevance 1.93 Pain Relevance 0.66
Inhibition of TLR7 and TLR9 with the immunoregulatory sequence 954 inhibited the induction of IFN-?
Negative_regulation (Inhibition) of TLR9
5) Confidence 0.22 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.83 Pain Relevance 0.18
RIIb expression that we observed on naïve B cells as a consequence of anti-TNF therapy is accompanied by a decrease in the expression of activating receptors on these cells, like TLR9 and CD21, which would determine a restoration of the protective activator/inhibitor balance, but this issue needs to be investigated.
Negative_regulation (decrease) of TLR9 in B cells
6) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888223 Disease Relevance 0.24 Pain Relevance 0.18
Similarly contradicting findings have been described for the TLRs: although important in vitro [38], TLR2, TLR4, or mice triply deficient in TLR2, TLR4 and TLR9 [5], [6], [39] were infected with mycobacteria, no susceptibility to Mtb was observed.
Negative_regulation (deficient) of TLR9 associated with mycobacterial infection
7) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794535 Disease Relevance 0.39 Pain Relevance 0
These results suggest that, although TLR3 and TLR9 receptors are reduced during the aging process, poly (ICLC) and CpG ODN still have potential to be effective.

6.

Negative_regulation (reduced) of TLR9 in poly associated with aging
8) Confidence 0.10 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.59 Pain Relevance 0.03

General Comments

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