INT260425

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.88
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tlr7) signal transduction (Tlr7) endoplasmic reticulum (Tlr7)
plasma membrane (Tlr7) intracellular (Tlr7) lysosome (Tlr7)
Tlr7 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 32 99.20 Very High Very High Very High
Inflammatory response 2 92.72 High High
agonist 25 75.40 Quite High
cytokine 70 72.12 Quite High
cINOD 1 48.88 Quite Low
corticosteroid 1 47.20 Quite Low
rheumatoid arthritis 5 29.00 Quite Low
Central nervous system 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 29 99.92 Very High Very High Very High
INFLAMMATION 34 99.20 Very High Very High Very High
Targeted Disruption 2 99.14 Very High Very High Very High
Genetic Translocation 1 97.44 Very High Very High Very High
Systemic Lupus Erythematosus 71 95.76 Very High Very High Very High
Renal Disease 3 89.00 High High
Sprains And Strains 18 81.04 Quite High
Disease 30 68.64 Quite High
Influenza Virus Infection 184 63.08 Quite High
Infection 70 57.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transgenic analysis of TLR7 determined that a modest increase in TLR7 expression resulted in spontaneous development of autoimmunity and a substantial increase in TLR7 expression caused fatal acute inflammation and profound DC dysregulation, indicating that TLR7 must be tightly regulated in order to prevent spontaneous triggering of harmful autoreactive and inflammatory responses [171].
Positive_regulation (increase) of Gene_expression (expression) of TLR7 associated with targeted disruption, inflammatory response, autoimmune disease and inflammation
1) Confidence 0.39 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.92 Pain Relevance 0.23
Transgenic analysis of TLR7 determined that a modest increase in TLR7 expression resulted in spontaneous development of autoimmunity and a substantial increase in TLR7 expression caused fatal acute inflammation and profound DC dysregulation, indicating that TLR7 must be tightly regulated in order to prevent spontaneous triggering of harmful autoreactive and inflammatory responses [171].
Positive_regulation (increase) of Gene_expression (expression) of TLR7 associated with targeted disruption, inflammatory response, autoimmune disease and inflammation
2) Confidence 0.39 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.96 Pain Relevance 0.23
Several subsequent studies have shown that the reason for the male bias in these mice was due to an X-to-Y chromosomal translocation of a gene cluster known as Y autoimmune accelerator (Yaa) and that the primary contributor to this accelerated autoimmunity is TLR 7 overexpression [16, 17].
Positive_regulation (overexpression) of Gene_expression (overexpression) of TLR 7 associated with autoimmune disease and genetic translocation
3) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 1.00 Pain Relevance 0.07

General Comments

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