INT260427

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Context Info
Confidence 0.33
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.42
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tlr7) signal transduction (Tlr7) endoplasmic reticulum (Tlr7)
plasma membrane (Tlr7) intracellular (Tlr7) lysosome (Tlr7)
Tlr7 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 1 99.68 Very High Very High Very High
Inflammation 24 98.40 Very High Very High Very High
antagonist 3 65.44 Quite High
agonist 13 61.92 Quite High
cytokine 42 58.64 Quite High
rheumatoid arthritis 5 37.24 Quite Low
Central nervous system 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 25 99.28 Very High Very High Very High
Autoimmune Disease 26 89.68 High High
Systemic Lupus Erythematosus 66 87.52 High High
Disease 23 85.20 High High
Targeted Disruption 1 84.80 Quite High
Sprains And Strains 10 51.04 Quite High
Influenza Virus Infection 92 49.60 Quite Low
Infection 35 44.48 Quite Low
Renal Disease 3 38.72 Quite Low
Rheumatoid Arthritis 5 37.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of TLR7 and TLR9 with the immunoregulatory sequence 954 inhibited the induction of IFN-?
Negative_regulation (Inhibition) of TLR7
1) Confidence 0.33 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.83 Pain Relevance 0.18
This oligodeoxynucleotide (ODN) was sufficient for inhibition of both TLR 7 and 9 signaling and protection against inflammation.
Negative_regulation (inhibition) of TLR 7 associated with inflammation
2) Confidence 0.07 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.59 Pain Relevance 0.24

General Comments

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