INT260436

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.65
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tlr9, Tlr7) signal transduction (Tlr9, Tlr7) endoplasmic reticulum (Tlr9, Tlr7)
plasma membrane (Tlr9, Tlr7) intracellular (Tlr9, Tlr7) lysosome (Tlr9, Tlr7)
Tlr9 (Mus musculus)
Tlr7 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 12 89.68 High High
cytokine 28 76.00 Quite High
sodium channel 1 10.64 Low Low
Inflammation 8 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Influenza Virus Infection 92 92.24 High High
Viral Infection 7 91.44 High High
Death 3 68.36 Quite High
Apoptosis 7 44.72 Quite Low
Infection 35 43.76 Quite Low
Sprains And Strains 8 34.40 Quite Low
Respiratory Syncytial Virus 7 30.08 Quite Low
Disease 7 13.36 Low Low
Toxicity 11 5.00 Very Low Very Low Very Low
INFLAMMATION 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Experimental analysis of sequential activation of TLR7, 8 and 9 in HEK293 cells demonstrated that activation of TLR9 inhibited TLR7 activation but not vice versa [207].
Positive_regulation (activation) of TLR9 Negative_regulation (inhibited) of Positive_regulation (activation) of TLR7
1) Confidence 0.14 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.65 Pain Relevance 0.20

General Comments

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