INT260447

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Context Info
Confidence 0.23
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.47
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HDAC1) nucleoplasm (HDAC1) nucleolus (HDAC1)
nucleus (HDAC1) enzyme binding (HDAC1) transcription factor binding (HDAC1)
HDAC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 108 99.20 Very High Very High Very High
rheumatoid arthritis 222 99.02 Very High Very High Very High
Inflammation 75 87.84 High High
Arthritis 15 69.76 Quite High
corticosteroid 6 39.20 Quite Low
methotrexate 12 16.96 Low Low
Inflammatory mediators 6 16.16 Low Low
cINOD 17 13.84 Low Low
cytokine 15 12.92 Low Low
antagonist 10 11.80 Low Low
Disease Link Frequency Relevance Heat
Frailty 114 99.20 Very High Very High Very High
Rheumatoid Arthritis 223 99.02 Very High Very High Very High
Cognitive Disorder 1 97.24 Very High Very High Very High
Colon Cancer 60 91.32 High High
Targeted Disruption 3 88.48 High High
INFLAMMATION 94 87.84 High High
Apoptosis 36 87.44 High High
Repression 12 79.44 Quite High
Cancer 282 79.04 Quite High
Cirrhosis 3 75.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effective degradation of p53 is mediated by the ubiquitin ligase Mdm2, as well as in RA [47], and Mdm2 can promote p53 deacetylation by recruiting a complex containing HDAC1 [48].
HDAC1 Binding (complex) of associated with rheumatoid arthritis
1) Confidence 0.23 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.20 Pain Relevance 0.33
Effective degradation of p53 is mediated by the ubiquitin ligase Mdm2, as well as in RA [47], and Mdm2 can promote p53 deacetylation by recruiting a complex containing HDAC1 [48].
HDAC1 Binding (recruiting) of associated with rheumatoid arthritis
2) Confidence 0.23 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.21 Pain Relevance 0.33
In RASFs, only HDAC1 mRNA and HDAC1 protein expression among class I HDACs increased through the time courses after TNF?
HDAC1 mRNA Binding (only) of
3) Confidence 0.23 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.13 Pain Relevance 0.46
These proteins localize to methylated promoter regions and recruit protein complexes containing HDACs, especially HDAC1, and histone methyltransferases (HMTs).
HDAC1 Binding (localize) of
4) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.42 Pain Relevance 0
HDAC class I and II interact with adaptor protein like mSin3A and transcriptional co-repressors N-CoR and SMRT to repress gene transcription [31].
HDAC class I Binding (interact) of
5) Confidence 0.17 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 0.12 Pain Relevance 0
-catenin by HDAC1/2 or the formation of ternary complex HDAC/?
HDAC1 Binding (catenin) of
6) Confidence 0.14 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.06 Pain Relevance 0
Thus, transcriptional co-repressors HDAC1 and HDAC2 compete with ?
HDAC1 Binding (compete) of
7) Confidence 0.14 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.07 Pain Relevance 0
For the present, I hope I have at least raised some key questions about the cognitive and practical relations between modalities in medicine, about the conditions under which they developed differently, and hence about the path dependency of their interactions.
path dependency Binding (interactions) of associated with cognitive disorder
8) Confidence 0.00 Published 2007 Journal Bull Hist Med Section Body Doc Link PMC2635842 Disease Relevance 0.25 Pain Relevance 0

General Comments

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