INT260470

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 0.11
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Casr) signal transducer activity (Casr)
Anatomy Link Frequency
G cells 4
parietal cells 1
Casr (Rattus norvegicus)
Casr - A986S (1)
Pain Link Frequency Relevance Heat
agonist 37 89.92 High High
nMDA receptor 9 66.12 Quite High
Calcitonin gene-related peptide 65 45.04 Quite Low
antagonist 11 43.80 Quite Low
Pain 1 36.28 Quite Low
Somatostatin 70 27.12 Quite Low
peptic ulcer disease 5 18.08 Low Low
nud 10 8.48 Low Low
Cholecystokinin 10 5.00 Very Low Very Low Very Low
ASIC 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 144 55.12 Quite High
Colon Cancer 35 50.00 Quite Low
Recurrence 16 50.00 Quite Low
Targeted Disruption 10 48.52 Quite Low
Cancer 20 42.16 Quite Low
Gastroesophageal Reflux Disease 5 39.52 Quite Low
Pain 1 36.28 Quite Low
Chronic Disease 1 32.76 Quite Low
Increased Venous Pressure Under Development 10 20.32 Low Low
Metastasis 2 19.44 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, CaSR is also present on antral G cells [28].
Gene_expression (present) of CaSR in G cells
1) Confidence 0.45 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0 Pain Relevance 0.08
Because the CaSR is present on the basolateral surface of G cells and parietal cells, one consideration is that exposure to the alkaline environments (eg, the alkaline tide after gastric secretion) would further enhance CaSR activation.
Gene_expression (present) of CaSR in parietal cells
2) Confidence 0.45 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0 Pain Relevance 0.08
The calcium-sensing receptor (CaSR), first described in the parathyroid gland but expressed on gastric G cells, is a logical candidate for the gastric acid sensor.
Gene_expression (expressed) of CaSR in G cells
3) Confidence 0.45 Published 2010 Journal Curr Gastroenterol Rep Section Abstract Doc Link PMC2974196 Disease Relevance 0 Pain Relevance 0
The calcium-sensing receptor (CaSR), first described in the parathyroid gland but expressed on gastric G cells, is a logical candidate for the gastric acid sensor.
Gene_expression (expressed) of calcium-sensing receptor in G cells
4) Confidence 0.39 Published 2010 Journal Curr Gastroenterol Rep Section Abstract Doc Link PMC2974196 Disease Relevance 0 Pain Relevance 0
Ten were not represented (AKAP9, BAIAP1, CASR, DLG2, EPHB4, GRIN3B, GUCY2C, GUCY2D, NPR2, and PRKCABP).
Neg (not) Gene_expression (represented) of CASR
5) Confidence 0.27 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 0.11 Pain Relevance 0.12
L) for CaSR A986S polymorphism contained 1 ?
Gene_expression (polymorphism) of CaSR A986S (A986S)
6) Confidence 0.21 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2636834 Disease Relevance 0 Pain Relevance 0
Because the CaSR is present on the basolateral surface of G cells and parietal cells, one consideration is that exposure to the alkaline environments (eg, the alkaline tide after gastric secretion) would further enhance CaSR activation.
Gene_expression (present) of CaSR in G cells
7) Confidence 0.15 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0 Pain Relevance 0.08

General Comments

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