INT260471

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Context Info
Confidence 0.61
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 8.37
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (Kdr) plasma membrane (Kdr) nucleus (Kdr)
cytoplasm (Kdr)
Anatomy Link Frequency
blood 3
pituitary 3
retina 2
endothelial cell 2
Kdr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
endometriosis 138 99.84 Very High Very High Very High
imagery 108 87.76 High High
cytokine 19 84.56 Quite High
Inflammation 7 78.28 Quite High
positron emission tomography 6 67.80 Quite High
ischemia 7 61.44 Quite High
nMDA receptor 9 50.00 Quite Low
metalloproteinase 9 50.00 Quite Low
ketamine 8 13.20 Low Low
corticosteroid 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 421 99.84 Very High Very High Very High
Endometriosis 198 99.84 Very High Very High Very High
Hypoxia 157 99.56 Very High Very High Very High
Diabetes Mellitus 206 99.48 Very High Very High Very High
Pituitary Cancer 24 97.56 Very High Very High Very High
Glioma 58 95.36 Very High Very High Very High
Disease 23 94.32 High High
INFLAMMATION 7 78.28 Quite High
Injury 5 77.80 Quite High
Breast Cancer 8 76.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our model, we were able to demonstrate that the expression of VEGF and Flk-1 is enhanced in endometriotic lesions as compared with controls.
Positive_regulation (enhanced) of Gene_expression (expression) of Flk-1 associated with endometriosis
1) Confidence 0.61 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2826344 Disease Relevance 0.98 Pain Relevance 0.38
The overexpression of VEGF-A and FLK-1 that was found in the diabetic retina in this study, in association with increased albumin leakage, supports the hypothesis that FLK-1 is another important permeability factor and regulator of BRB dysfunction in diabetes.
Positive_regulation (overexpression) of Gene_expression (overexpression) of FLK-1 in retina associated with diabetes mellitus
2) Confidence 0.44 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.62 Pain Relevance 0
In addition, Wang et al. (2005) [29] reported a higher Flk-1 expression in endometriosis lesions of the peritoneal and abdominal wall, which may have been associated with neovascularization.
Positive_regulation (higher) of Gene_expression (expression) of Flk-1 associated with endometriosis
3) Confidence 0.41 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2826344 Disease Relevance 0.89 Pain Relevance 0.23
Similarly, FLK-1 expression was increased by 1.6-fold in the sham-treated diabetic retinas compared with that in sham-treated nondiabetic retinas (53.17 ± 1.08 vs. 32.95 ± 0.47 positive cells/mm, P < 0.0001).
Positive_regulation (increased) of Gene_expression (expression) of FLK-1 associated with diabetes mellitus
4) Confidence 0.41 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.75 Pain Relevance 0
Banerjee et al. [2] demonstrated that the expression of VEGF and its receptor, Flk-1 protein, was enhanced significantly in the pituitary after 7 days of treatment with estrogen, and the level of gene expression markedly accelerated during prolonged estrogen exposure.
Positive_regulation (enhanced) of Gene_expression (expression) of Flk-1 protein in pituitary
5) Confidence 0.38 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875861 Disease Relevance 0.21 Pain Relevance 0.03
Increased expression levels of VEGF and Flk-1 have been reported in the peripheral blood of patients with pituitary tumors [30].
Positive_regulation (Increased) of Gene_expression (expression) of Flk-1 in blood associated with pituitary cancer
6) Confidence 0.38 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875861 Disease Relevance 0.57 Pain Relevance 0
The expression of VEGF, Flk-1, and EPO were significantly upregulated following hypoxia.
Positive_regulation (upregulated) of Gene_expression (expression) of Flk-1 associated with hypoxia
7) Confidence 0.28 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 0.88 Pain Relevance 0
Increased expression levels of VEGF and Flk-1 have been reported in the peripheral blood of patients with pituitary tumors [30].
Positive_regulation (Increased) of in blood Gene_expression (levels) of Flk-1 in pituitary associated with pituitary cancer
8) Confidence 0.26 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875861 Disease Relevance 0.57 Pain Relevance 0
Since VEGFR2 is over expressed in tumor vasculature (40,000 copies/endothelial cell) and has a high binding affinity (Ka?
Positive_regulation (Since) of Gene_expression (expressed) of VEGFR2 in endothelial cell associated with cancer
9) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806917 Disease Relevance 0.83 Pain Relevance 0.17
The expression of VEGFR2 detected by Tc-99m-HYNIC-VEGF SPECT was also significantly increased in the treated tumors.
Positive_regulation (increased) of Gene_expression (expression) of VEGFR2 associated with cancer
10) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806917 Disease Relevance 1.02 Pain Relevance 0.15
The increase in the expression of the receptors Flk-1 and Tie-2 that we observed upon gene therapy can be correlated to the increased expression of their ligands: VEGF and Ang-1, respectively.
Positive_regulation (increase) of Gene_expression (expression) of Flk-1
11) Confidence 0.12 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 1.05 Pain Relevance 0.03

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