INT260481

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Context Info
Confidence 0.63
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.37
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grin2d) plasma membrane (Grin2d)
Anatomy Link Frequency
retinas 1
Grin2d (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 18 85.52 High High
Glutamate receptor 8 64.16 Quite High
Glutamate 4 63.32 Quite High
Calcium channel 2 52.04 Quite High
antagonist 2 29.04 Quite Low
adenocard 6 21.04 Low Low
potassium channel 6 14.88 Low Low
nMDA receptor antagonist 2 10.88 Low Low
isoflurane 12 5.00 Very Low Very Low Very Low
anesthesia 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 288 99.84 Very High Very High Very High
Ganglion Cysts 18 72.48 Quite High
Diabetic Retinopathy 8 68.12 Quite High
Glaucoma 4 67.12 Quite High
Retinal Diseases 6 66.64 Quite High
Stress 10 55.64 Quite High
Death 2 53.48 Quite High
Apoptosis 8 5.00 Very Low Very Low Very Low
Decapitation 6 5.00 Very Low Very Low Very Low
Diabetes Mellitus 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also found significant increases in NR2C and NR2D subunits, but not in NR2A or NR2B.
Positive_regulation (increases) of NR2D
1) Confidence 0.63 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 0.97 Pain Relevance 0.10
NR1, NR2C, and NR2D were significantly elevated in hypoxic retinas compared with controls; these results were in close agreement with the microarray results (Figure 4).


Positive_regulation (elevated) of NR2D in retinas associated with hypoxia
2) Confidence 0.37 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 0.40 Pain Relevance 0.13

General Comments

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