INT260496

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Context Info
Confidence 0.12
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.93
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Hif1a, VEGFA) cell differentiation (Hif1a) protein binding transcription factor activity (Hif1a)
DNA binding (Hif1a) signal transducer activity (Hif1a) extracellular space (VEGFA)
Anatomy Link Frequency
retina 2
Hif1a (Rattus norvegicus)
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 9 50.00 Quite Low
isoflurane 6 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Glutamate receptor 4 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
potassium channel 3 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 144 99.16 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 2 91.24 High High
Retinal Diseases 3 68.76 Quite High
Glaucoma 2 51.20 Quite High
Retinopathy 1 46.80 Quite Low
Diabetic Retinopathy 4 45.32 Quite Low
Ganglion Cysts 9 43.76 Quite Low
Diabetes Mellitus 3 34.56 Quite Low
Disease 3 19.16 Low Low
Retina Disease 2 10.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, the regulatory subunit of HIF-1, and increased VEGF expression have been shown, indicating that HIF-1 may control the expression of VEGF in the retina under hypoxic conditions.
HIF-1 Spec (may) Regulation (control) of Gene_expression (expression) of VEGF in retina associated with hypoxia
1) Confidence 0.12 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 0.93 Pain Relevance 0

General Comments

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