INT2605

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Context Info
Confidence 0.61
First Reported 1979
Last Reported 2010
Negated 5
Speculated 3
Reported most in Abstract
Documents 39
Total Number 44
Disease Relevance 18.22
Pain Relevance 7.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ELANE) extracellular region (ELANE) cytoplasm (ELANE)
Anatomy Link Frequency
neutrophil 8
granulocyte 6
leukocyte 4
plasma 2
adrenal glands 2
ELANE (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 287 100.00 Very High Very High Very High
anesthesia 31 100.00 Very High Very High Very High
agonist 18 100.00 Very High Very High Very High
Clonidine 5 100.00 Very High Very High Very High
Pain 17 99.98 Very High Very High Very High
antidepressant 2 99.68 Very High Very High Very High
Chronic pancreatitis 6 98.80 Very High Very High Very High
diclofenac 3 98.16 Very High Very High Very High
Osteoarthritis 222 97.40 Very High Very High Very High
metalloproteinase 47 97.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 321 100.00 Very High Very High Very High
Stress 130 100.00 Very High Very High Very High
Injury 31 100.00 Very High Very High Very High
Sepsis 15 100.00 Very High Very High Very High
Shock 23 99.98 Very High Very High Very High
Pain 13 99.68 Very High Very High Very High
Cancer 24 99.00 Very High Very High Very High
Urological Neuroanatomy 7 98.96 Very High Very High Very High
Pancreatitis 9 98.80 Very High Very High Very High
Necrosis 10 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of Nonsteroidal Anti-inflammatory Drugs on the Activity of Elastase and Cathepsin G from Human Polymorphonuclear Leukocytes.
Regulation (Effect) of Elastase in Leukocytes associated with inflammation
1) Confidence 0.61 Published 1989 Journal Arzneimittelforschung Section Abstract Doc Link 2610712 Disease Relevance 0.27 Pain Relevance 0.28
[The effect of anti-inflammatory agents on the granulocyte enzymes elastase and cathepsin G].
Regulation (effect) of elastase in granulocyte associated with inflammation
2) Confidence 0.53 Published 1989 Journal Arzneimittelforschung Section Title Doc Link 2610712 Disease Relevance 0.29 Pain Relevance 0.31
Median PMN elastase plasma levels were not affected by hydrocortisone infusion.
Neg (not) Regulation (affected) of elastase in plasma
3) Confidence 0.51 Published 2005 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 15843228 Disease Relevance 0.66 Pain Relevance 0.03
In assessing the elevated NE epilepsy hypothesis, the following seven lines of evidence are examined that include studies of: (1) antidepressants that raise the level of NE; (2) clonidine and other alpha 2 adrenergic agonist drugs that lower the level of NE; (3) prazosin and other drugs that affect alpha adrenoceptors; (4) propranolol and other drugs that affect beta adrenoceptors; (5) pheochromocytoma, which is a rare cancer of the adrenal glands that can boost NE levels; (6) comorbidity of epilepsy with bipolar disorder, hypertension, and obesity, where all four conditions may involve elevated NE; and (7) psychological stress, which is associated with increased release of NE.
Regulation (level) of NE in adrenal glands associated with stress, adrenal cancer, pheochromocytoma, clonidine, epilepsy, antidepressant, manic depressive disorder, obesity, agonist and hypertension
4) Confidence 0.39 Published 2010 Journal Seizure Section Abstract Doc Link 20493725 Disease Relevance 0.89 Pain Relevance 0.33
In assessing the elevated NE epilepsy hypothesis, the following seven lines of evidence are examined that include studies of: (1) antidepressants that raise the level of NE; (2) clonidine and other alpha 2 adrenergic agonist drugs that lower the level of NE; (3) prazosin and other drugs that affect alpha adrenoceptors; (4) propranolol and other drugs that affect beta adrenoceptors; (5) pheochromocytoma, which is a rare cancer of the adrenal glands that can boost NE levels; (6) comorbidity of epilepsy with bipolar disorder, hypertension, and obesity, where all four conditions may involve elevated NE; and (7) psychological stress, which is associated with increased release of NE.
Regulation (level) of NE in adrenal glands associated with stress, adrenal cancer, pheochromocytoma, clonidine, epilepsy, antidepressant, manic depressive disorder, obesity, agonist and hypertension
5) Confidence 0.39 Published 2010 Journal Seizure Section Abstract Doc Link 20493725 Disease Relevance 0.87 Pain Relevance 0.32
Three alginate-based wound dressings: alginate alone, alginate containing ionic silver, and alginate with nanocrystalline silver, were tested for biocompatibility, antimicrobial activity, and influence on chronic wound parameters such as elastase, matrix metalloproteases-2, tumor necrosis factor-alpha, interleukin-8, and free radical formation.
Regulation (influence) of elastase associated with necrosis, cancer and injury
6) Confidence 0.39 Published 2009 Journal Wound Repair Regen Section Abstract Doc Link 19614916 Disease Relevance 1.27 Pain Relevance 0.23
Change in the concentration of neutrophil elastase in bronchoalveolar lavage fluid during anesthesia and its inhibition by cholesterol sulfate.
Regulation (Change) of elastase in neutrophil associated with anesthesia
7) Confidence 0.39 Published 2006 Journal Transl Res Section Title Doc Link 16890150 Disease Relevance 0.23 Pain Relevance 0.21
[Changes in granulocyte elastase caused by the use of ulinastatin during anesthesia for renal transplantation].
Regulation (Changes) of granulocyte elastase in granulocyte associated with anesthesia
8) Confidence 0.38 Published 1991 Journal Masui Section Title Doc Link 1942515 Disease Relevance 0.21 Pain Relevance 0.24
The objective of this study was to demonstrate the effect of stress doses of hydrocortisone during the initial phase of human septic shock on the serum values of the neurospecific protein S-100B in comparison to the inflammation markers interleukin (IL)-8 in serum and polymorphonuclear (PMN) elastase in plasma.
Regulation (effect) of elastase in plasma associated with stress, inflammation and sepsis
9) Confidence 0.38 Published 2005 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 15843228 Disease Relevance 1.09 Pain Relevance 0.15
[Clinical value of PMN elastase activity before reperfusion therapy in acute myocardial infarction: comparison with clinical characteristics, reperfusion events and myocardial damage].
Regulation (value) of PMN elastase associated with myocardial infarction
10) Confidence 0.27 Published 1992 Journal Kokyu To Junkan Section Title Doc Link 1439293 Disease Relevance 0.49 Pain Relevance 0.11
Zorn et al. [29] indicated a better sensitivity of granulocyte elastase compared with leukocyte count as a genitourinary tract inflammation marker in men.
Regulation (sensitivity) of granulocyte elastase in leukocyte associated with inflammation
11) Confidence 0.25 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2778713 Disease Relevance 0.88 Pain Relevance 0.33
The concentrations of CS and neutrophil elastase were determined by thin-layer chromatography and enzyme-linked immunosorbent assaying, respectively, and the effect of CS on the activity of elastase was determined with a chromogenic substrate.
Regulation (concentrations) of elastase in neutrophil
12) Confidence 0.24 Published 2006 Journal Transl Res Section Abstract Doc Link 16890150 Disease Relevance 0.23 Pain Relevance 0.20
To clarify the possible role of CS for protection from the epithelial injury due to neutrophil elastase in the tracheobronchi, the authors determined the concentrations of CS and neutrophil elastase in bronchoalveolar lavage fluid (BALF) from patients under anesthesia, and they examined the inhibitory activity of CS toward neutrophil elastase.
Spec (determined) Regulation (concentrations) of elastase in neutrophil associated with anesthesia and injury
13) Confidence 0.24 Published 2006 Journal Transl Res Section Abstract Doc Link 16890150 Disease Relevance 0.19 Pain Relevance 0.17
Since the clinical symptoms of agranulocytosis and SCN are similar, we hypothesized that it may origin from a common genetic variation in ELA2 or that sulphasalazine may affect human neutrophil elastase activity and protein expression.


Spec (may) Regulation (affect) of elastase in neutrophil associated with agranulocytosis and neutrophil disorders
14) Confidence 0.23 Published 2004 Journal BMC Blood Disord Section Abstract Doc Link PMC535939 Disease Relevance 0.84 Pain Relevance 0.04
Pharmacological influence on polymorphonuclear granulocytes elastase under various test conditions.
Regulation (influence) of elastase in granulocytes
15) Confidence 0.23 Published 1990 Journal Arzneimittelforschung Section Title Doc Link 2334461 Disease Relevance 0 Pain Relevance 0.12
Collectively, these data suggest that Egr-1 may be one of the transcription factors involved in HNE-induced mPGES-1 promoter activity.


Regulation (involved) of HNE-induced
16) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.18 Pain Relevance 0.09
Single or repeated HNE treatments regulate differently PGE2 release and COX-2 protein expression
Regulation (repeated) of HNE
17) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0 Pain Relevance 0
[Effect of pancreatic substitutes on fecal and serum elastase and on pain in patients with chronic pancreatitis].
Regulation (Effect) of serum elastase associated with pain and chronic pancreatitis
18) Confidence 0.15 Published 2000 Journal Vnitr Lek Section Title Doc Link 11227180 Disease Relevance 0.65 Pain Relevance 0.67
The purpose of this study was to evaluate the influence of ulinastatin (UST) on renal function and changes in granulocyte elastase during anesthesia in 10 living related and 10 cadaveric renal transplantations.
Regulation (changes) of granulocyte elastase in granulocyte associated with anesthesia
19) Confidence 0.15 Published 1994 Journal Masui Section Abstract Doc Link 8189615 Disease Relevance 0.06 Pain Relevance 0.26
The inventory of HNE-modified proteins contained several heat shock proteins, including Hsp60, GRP78, Hsp70 (Hsp72), and Hsp90.(19) Likewise, microarray data revealed a dramatic increase in heat shock-regulated transcripts in HNE-treated RKO cells.(21) The inducible expression of heat shock genes caused by heat or chemical stress is principally controlled by the latent transcription factor, heat shock factor 1 (HSF1).
Regulation (regulated) of HNE in RKO associated with stress and shock
20) Confidence 0.15 Published 2010 Journal Accounts of Chemical Research Section Body Doc Link PMC2873822 Disease Relevance 0.94 Pain Relevance 0

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