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Context Info
Confidence 0.67
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.31
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (AKR1B1) carbohydrate metabolic process (AKR1B1) response to stress (AKR1B1)
cytoplasm (AKR1B1) cytosol (AKR1B1) extracellular space (AKR1B1)
Anatomy Link Frequency
external 1
AKR1B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 10 99.08 Very High Very High Very High
agonist 12 97.92 Very High Very High Very High
Migraine 77 92.04 High High
Inflammation 29 50.00 Quite Low
Opioid 14 42.96 Quite Low
Analgesic 4 42.40 Quite Low
corticosteroid 3 39.84 Quite Low
cytokine 16 33.52 Quite Low
Inflammatory response 2 29.12 Quite Low
antagonist 9 17.84 Low Low
Disease Link Frequency Relevance Heat
Adverse Drug Reaction 221 100.00 Very High Very High Very High
Migraine Without Aura 10 99.32 Very High Very High Very High
Hyperglycemia 38 99.30 Very High Very High Very High
Stress 33 97.60 Very High Very High Very High
Headache 69 92.04 High High
Diabetes Mellitus 84 85.44 High High
Migraine With Aura 30 83.04 Quite High
Injury 5 72.80 Quite High
Apoptosis 90 71.84 Quite High
Disease 22 63.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However once patients were divided into subgroups, MO patients presented a significant increase of the HLADRB* 16 allele.
Positive_regulation (increase) of ADR associated with migraine without aura
1) Confidence 0.67 Published 2007 Journal J Headache Pain Section Body Doc Link PMC2779399 Disease Relevance 1.29 Pain Relevance 0.57
This is however likely to be an underestimate since the direct and indirect costs to patients such as loss of earnings due to extended stay or increased morbidity have not been measured, and neither were the costs which could be attributed to treating ADRs such as the prescribing of more medication and investigations, and involvement of clinical team external to the specialty to which the patient was admitted, all of which add to the overall ADR burden.
Positive_regulation (overall) of ADR in external associated with adverse drug reaction
2) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635959 Disease Relevance 0.46 Pain Relevance 0
The frequency of the drug group causing a suspected ADR was divided by the number of times a drug in that class was administered in the control sample of patients (if?
Positive_regulation (causing) of ADR
3) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635959 Disease Relevance 0.40 Pain Relevance 0
Our study confirmed the high rate of ADR of ?
Positive_regulation (rate) of ADR associated with adverse drug reaction
4) Confidence 0.11 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971730 Disease Relevance 1.36 Pain Relevance 0.09
Oxidative stress is probably a key event in endothelial dysfunction since inhibition of hyperglycemia, induced, ROS production prevents activation of the aldose reductase, hexosamine pathways, PKC activation, and AGE formation [77, 89].
Positive_regulation (activation) of aldose reductase associated with hyperglycemia, stress and kinase c
5) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 0.80 Pain Relevance 0.05

General Comments

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