INT260508

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Context Info
Confidence 0.07
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 2.60
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Zfp941) cellular_component (Zfp941) biological_process (Zfp941)
Anatomy Link Frequency
brain 2
spleen 1
Zfp941 (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 5 93.52 High High
anesthesia 10 54.88 Quite High
Inflammation 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 120 99.60 Very High Very High Very High
Sprains And Strains 45 98.28 Very High Very High Very High
Paresis 5 98.04 Very High Very High Very High
Scrapie 60 98.00 Very High Very High Very High
Disease 60 97.68 Very High Very High Very High
Congenital Anomalies 5 79.32 Quite High
Infection 20 64.32 Quite High
Death 5 52.92 Quite High
Leukoencephalopathies 5 52.48 Quite High
Drug Induced Neurotoxicity 5 36.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of PrPmyc in Tg941 was approximately 0.33 fold in brain and 2-fold in spleen of PrPC expression in Prnp+/o mice (data not shown).
Gene_expression (Expression) of Tg941 in spleen
1) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635968 Disease Relevance 0.48 Pain Relevance 0.04
As Tg941 mice express about one-third of the PrPmyc found in brains of Tg940 mice, this indicates that the action of PrPmyc, like that of PrPC, is dose-dependent.


Gene_expression (express) of Tg941 in brains
2) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635968 Disease Relevance 0.50 Pain Relevance 0
To obtain transgenic strains that only expressed PrPmyc yet no endogenous PrP, both transgenic founders Tg940 and Tg941 were crossed twice to Prnpo/o mice.
Gene_expression (crossed) of Tg941 associated with targeted disruption and sprains and strains
3) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635968 Disease Relevance 0.61 Pain Relevance 0.05
Mice expressing less PrPmyc in brain (Tg941) developed signs of CNS dysfunction and terminal scrapie disease more slowly, at 316±20 (n?
Gene_expression (expressing) of Tg941 in brain associated with scrapie and disease
4) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635968 Disease Relevance 0.65 Pain Relevance 0.05
The two highest-expressing lines, termed Tg(PrPmyc)940Zbz and Tg(PrPmyc)941Zbz (henceforth Tg940 and Tg941 for brevity) were chosen for further propagation.
Gene_expression (expressing) of Tg941
5) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635968 Disease Relevance 0.35 Pain Relevance 0

General Comments

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