INT260525

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Context Info
Confidence 0.66
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 25
Total Number 25
Disease Relevance 24.58
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (AMD1) small molecule metabolic process (AMD1) lyase activity (AMD1)
cellular nitrogen compound metabolic process (AMD1)
Anatomy Link Frequency
eyes 3
arm 1
AMD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 134 99.64 Very High Very High Very High
alcohol 5 93.84 High High
Pain 17 90.80 High High
cva 50 84.28 Quite High
corticosteroid 5 84.08 Quite High
cINOD 5 82.20 Quite High
Potency 3 71.84 Quite High
withdrawal 13 22.32 Low Low
iatrogenic 3 19.60 Low Low
ischemia 8 5.84 Low Low
Disease Link Frequency Relevance Heat
Age-related Macular Degeneration 2055 100.00 Very High Very High Very High
Diabetic Retinopathy 141 100.00 Very High Very High Very High
Geographic Atrophy 90 99.86 Very High Very High Very High
Disease 277 99.72 Very High Very High Very High
INFLAMMATION 135 99.64 Very High Very High Very High
Diabetes Mellitus 345 98.96 Very High Very High Very High
Retinal Diseases 36 98.60 Very High Very High Very High
Cicatrix 10 97.84 Very High Very High Very High
Endophthalmitis 38 94.32 High High
Nicotine Addiction 40 94.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The difference in progression rates of AMD and incidence of late AMD will be compared between the two treatment groups.
Gene_expression (rates) of AMD associated with age-related macular degeneration
1) Confidence 0.66 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682391 Disease Relevance 0.26 Pain Relevance 0
The recent genetic and pathological findings implicating the complement pathway and inflammation in the etiology of AMD (Edwards et al 2005; Hageman et al 2005; Haines et al 2005; Klein et al 2005) suggest that the anti-inflammatory actions of statins may also be valuable in AMD.
Gene_expression (valuable) of AMD associated with inflammation and age-related macular degeneration
2) Confidence 0.57 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682391 Disease Relevance 0.87 Pain Relevance 0.10
The primary objective of this randomized controlled trial is progression of AMD, either to the development of late stage AMD, defined as either CNV or central geographic atrophy or as progression through stages of early AMD.
Gene_expression (progression) of AMD associated with age-related macular degeneration and geographic atrophy
3) Confidence 0.57 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682391 Disease Relevance 1.28 Pain Relevance 0.09
This is similar to the variability found with clinical perimetry (Demirel and Vingrys 1994) indicating that our method has potential as a clinical application for the early detection of persons with AMD (Dimitrov et al 2008).


Gene_expression (detection) of AMD associated with age-related macular degeneration
4) Confidence 0.57 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682391 Disease Relevance 0.58 Pain Relevance 0.04
The primary objective of this randomized controlled trial is progression of AMD, either to the development of late stage AMD, defined as either CNV or central geographic atrophy or as progression through stages of early AMD.
Gene_expression (progression) of AMD associated with age-related macular degeneration and geographic atrophy
5) Confidence 0.57 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682391 Disease Relevance 1.32 Pain Relevance 0.09
The primary objective of this randomized controlled trial is progression of AMD, either to the development of late stage AMD, defined as either CNV or central geographic atrophy or as progression through stages of early AMD.
Gene_expression (progression) of AMD associated with age-related macular degeneration and geographic atrophy
6) Confidence 0.57 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682391 Disease Relevance 1.41 Pain Relevance 0.09
Emerging knowledge about AMD genetics and pathology suggests a possible role for statins in prevention and delaying progression of AMD.
Gene_expression (progression) of AMD associated with age-related macular degeneration
7) Confidence 0.57 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682391 Disease Relevance 1.04 Pain Relevance 0.05
Progression of early AMD
Gene_expression (Progression) of AMD associated with age-related macular degeneration
8) Confidence 0.57 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682391 Disease Relevance 2.37 Pain Relevance 0.05
Progression to late AMD
Gene_expression (Progression) of AMD associated with age-related macular degeneration
9) Confidence 0.57 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682391 Disease Relevance 1.55 Pain Relevance 0.08
The sample size calculation was based on AMD change measured (1) traditionally, by visual/photographic detection, and (2) by detection of significant changes in visual sensitivity and the time of rod-cone break in dark adaptation.
Gene_expression (change) of AMD associated with age-related macular degeneration
10) Confidence 0.57 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682391 Disease Relevance 0.30 Pain Relevance 0
To detect a similar reduction in AMD progression, a sample size of 118 subjects in each arm, followed for three years, was needed to reach 80% power at a 5% level of significance.
Gene_expression (progression) of AMD in arm associated with age-related macular degeneration
11) Confidence 0.57 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682391 Disease Relevance 0.36 Pain Relevance 0
Emerging knowledge about AMD genetics and pathology suggests a possible role for statins in prevention and delaying progression of AMD.
Gene_expression (genetics) of AMD associated with age-related macular degeneration
12) Confidence 0.57 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682391 Disease Relevance 1.01 Pain Relevance 0.05
The difference in progression rates of AMD and incidence of late AMD will be compared between the two treatment groups.
Gene_expression (rates) of AMD associated with age-related macular degeneration
13) Confidence 0.51 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682391 Disease Relevance 0.26 Pain Relevance 0
Although the current evidence base is inconclusive, it is expected that the inflammatory repair responses present in both diabetic retinopathy and neovascular AMD may be cumulative and may be compounded when wet AMD is present in eyes of patients with diabetic retinal disease.
Gene_expression (present) of AMD in eyes associated with inflammation, diabetes mellitus, age-related macular degeneration, diabetic retinopathy and retinal diseases
14) Confidence 0.46 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2693968 Disease Relevance 1.17 Pain Relevance 0.18
Distinction between diabetic retinopathy and wet AMD
Gene_expression (retinopathy) of AMD associated with age-related macular degeneration and diabetic retinopathy
15) Confidence 0.46 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2693968 Disease Relevance 1.75 Pain Relevance 0.05
In clinical trials (Brown et al 2006; Rosenfeld et al 2006), the agent has demonstrated that it not only stabilizes the progression of neovascular AMD, but can also lead to an improvement in vision in patients with specific subtypes of the disease.
Gene_expression (progression) of AMD associated with disease and age-related macular degeneration
16) Confidence 0.46 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2693968 Disease Relevance 0.72 Pain Relevance 0
Distinction between diabetic retinopathy and wet AMD
Gene_expression (Distinction) of AMD associated with age-related macular degeneration and diabetic retinopathy
17) Confidence 0.46 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2693968 Disease Relevance 1.81 Pain Relevance 0.05
Although the current evidence base is inconclusive, it is expected that the inflammatory repair responses present in both diabetic retinopathy and neovascular AMD may be cumulative and may be compounded when wet AMD is present in eyes of patients with diabetic retinal disease.
Gene_expression (present) of AMD in eyes associated with inflammation, diabetes mellitus, age-related macular degeneration, diabetic retinopathy and retinal diseases
18) Confidence 0.41 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2693968 Disease Relevance 1.20 Pain Relevance 0.17
It is particularly noteworthy that these compounds appear, for the first time, to provide a treatment for neovascular AMD producing significant improvements in visual acuity.
Gene_expression (producing) of AMD associated with age-related macular degeneration
19) Confidence 0.26 Published 2006 Journal Clinical Interventions in Aging Section Body Doc Link PMC2699647 Disease Relevance 0.41 Pain Relevance 0.07
Following monthly intravitreal injections of ranibizumab for AMD, patients?
Gene_expression (injections) of AMD associated with age-related macular degeneration
20) Confidence 0.17 Published 2007 Journal Indian Journal of Ophthalmology Section Body Doc Link PMC2635972 Disease Relevance 0.35 Pain Relevance 0.09

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