INT260564

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.96
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos3) Golgi apparatus (Nos3) cytoplasm (Nos3)
signal transduction (Nos3) oxidoreductase activity (Nos3) nucleolus (Nos3)
Nos3 (Mus musculus)
T2dm2 (Mus musculus)
Pain Link Frequency Relevance Heat
Bioavailability 18 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 222 100.00 Very High Very High Very High
Myocardial Infarction 93 100.00 Very High Very High Very High
Nicotine Addiction 33 94.64 High High
Disorder Of Lipid Metabolism 42 93.44 High High
Hypertension 51 79.92 Quite High
Atherosclerosis 12 46.80 Quite Low
Cardiovascular Disease 33 5.00 Very Low Very Low Very Low
Endometriosis (extended) 18 5.00 Very Low Very Low Very Low
Coronary Artery Disease 15 5.00 Very Low Very Low Very Low
Insulin Resistance 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found a significant risk for AMI associated with the Asp298/Asp298 genotype compared to the wild type Glu298/Glu298 among patients with T2DM (HR 3.12 CI [1.49–6.56], p = 0.003) but no association between eNOS genotype and AMI in subjects without T2DM (HR 0.45 [0.18–1.11], p = 0.083).
eNOS Neg (no) Binding (association) of T2DM associated with diabetes mellitus and myocardial infarction
1) Confidence 0.05 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2636751 Disease Relevance 1.44 Pain Relevance 0
T2DM (HR 4.04 [2.61–6.27], p < 0.001) was an independent risk factor for AMI in a multivariate model (adjusted for age and sex), and remained significant when also entering the eNOS Asp298 dichotomized using a recessive model (Asp298/Asp298 versus Asp298/Glu298+ Glu298/Glu298).
eNOS Binding (entering) of T2DM associated with diabetes mellitus and myocardial infarction
2) Confidence 0.04 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2636751 Disease Relevance 0.84 Pain Relevance 0
We show here a strong independent association between eNOS genotype and AMI in patients with T2DM.
eNOS Binding (association) of T2DM associated with diabetes mellitus and myocardial infarction
3) Confidence 0.04 Published 2008 Journal BMC Cardiovasc Disord Section Abstract Doc Link PMC2636751 Disease Relevance 1.68 Pain Relevance 0

General Comments

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