INT26058

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Context Info
Confidence 0.23
First Reported 1989
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 2.81
Pain Relevance 4.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (SH3BP5) mitochondrion (SH3BP5) intracellular (SH3BP5)
cytoplasm (SH3BP5)
Anatomy Link Frequency
SH-SY5Y 10
neuronal 1
H-4-II-E 1
SH3BP5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 25 100.00 Very High Very High Very High
Dopamine 7 99.22 Very High Very High Very High
qutenza 18 99.04 Very High Very High Very High
Morphine 243 98.84 Very High Very High Very High
dorsal root ganglion 7 97.84 Very High Very High Very High
Neurotransmitter 5 97.60 Very High Very High Very High
diclofenac 80 96.36 Very High Very High Very High
opioid receptor 77 95.76 Very High Very High Very High
agonist 59 94.80 High High
vanilloid receptor subtype 1 3 94.04 High High
Disease Link Frequency Relevance Heat
Neuroblastoma 55 100.00 Very High Very High Very High
Rheumatoid Arthritis 5 99.32 Very High Very High Very High
Ganglion Cysts 7 97.84 Very High Very High Very High
Anaplastic Astrocytoma 1 97.28 Very High Very High Very High
Hepatocellular Cancer 4 96.96 Very High Very High Very High
Death 9 95.56 Very High Very High Very High
Injury 5 92.52 High High
Pain 11 69.80 Quite High
Toxicity 33 62.48 Quite High
Apoptosis 46 59.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, the human SH-SY5Y and rat N2a neuroblastoma cell lines produced quite different response patterns, as did the human HepG2 and rat H-4-II-E hepatoma lines.
Gene_expression (produced) of SH-SY5Y in H-4-II-E associated with neuroblastoma and hepatocellular cancer
1) Confidence 0.23 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2265061 Disease Relevance 0.34 Pain Relevance 0
We report the establishment of the first neuronal model expressing recombinant human TRPV1 (SH-SY5Y(hTRPV1)).
Gene_expression (expressing) of SH-SY5Y in SH-SY5Y
2) Confidence 0.16 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17442052 Disease Relevance 0.25 Pain Relevance 0.42
SH-SY5Y human neuroblastoma cells were stably transfected with hTRPV1 using the Amaxa Biosystem (hTRPV1 in pIREShyg2 with hygromycin selection).
Gene_expression (transfected) of SH-SY5Y in SH-SY5Y associated with neuroblastoma
3) Confidence 0.14 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17442052 Disease Relevance 0.25 Pain Relevance 0.44
Activation of recombinant human TRPV1 receptors expressed in SH-SY5Y human neuroblastoma cells increases [Ca(2+)](i), initiates neurotransmitter release and promotes delayed cell death.
Gene_expression (expressed) of SH-SY5Y in SH-SY5Y associated with neuroblastoma, neurotransmitter, qutenza and death
4) Confidence 0.12 Published 2007 Journal J. Neurochem. Section Title Doc Link 17442052 Disease Relevance 0.28 Pain Relevance 0.71
Retinoic acid enhances VIP receptor expression and responsiveness in human neuroblastoma cell, SH-SY5Y.
Gene_expression (expression) of SH-SY5Y in SH-SY5Y associated with neuroblastoma
5) Confidence 0.05 Published 1989 Journal FEBS Lett. Section Title Doc Link 2546814 Disease Relevance 0.75 Pain Relevance 0.09
In mammals, the biosynthesis of endogenous morphine is associated with dopamine [5], [6], [7], as demonstrated in the SH-SY5Y human neuronal catecholamine-producing cell line [8], [9].
Gene_expression (producing) of SH-SY5Y in neuronal associated with dopamine, catecholamine and morphine
6) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808358 Disease Relevance 0.09 Pain Relevance 0.95
2-AR signaling following EPI treatment between the transfected and wt SH-SY5Y was attributable to the presence of functional ?
Gene_expression (transfected) of SH-SY5Y in SH-SY5Y
7) Confidence 0.01 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2234403 Disease Relevance 0 Pain Relevance 0.14
2-AR-transfected SH-SY5Y cells.
Gene_expression (transfected) of SH-SY5Y in SH-SY5Y
8) Confidence 0.01 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2234403 Disease Relevance 0 Pain Relevance 0
In contrast, no increased translocation of GRKs by EPI treatment was observed in wt SH-SY5Y cells that do not express ?
Neg (not) Gene_expression (express) of SH-SY5Y in SH-SY5Y
9) Confidence 0.01 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2234403 Disease Relevance 0 Pain Relevance 0
Additionally, MOR1K was expressed at high levels in the human neuroblastoma cell lines Be2C and SH-SY5Y, while no expression was observed in monkey kidney COS-1 and human astrocytoma H4 cell lines.
Neg (no) Gene_expression (expressed) of SH-SY5Y in SH-SY5Y associated with anaplastic astrocytoma and neuroblastoma
10) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2894766 Disease Relevance 0.47 Pain Relevance 0.48
To this aim, the dose- and time-dependent effects of this drug on SOD2 protein levels of SH-SY5Y cells were analysed in the experiments reported in Figure 3.
Gene_expression (levels) of SH-SY5Y in SH-SY5Y
11) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.21 Pain Relevance 0.37
The present study sought to determine the molecular mechanism(s) by which OFQ/N modulates the chronic actions of morphine by utilizing human neuroblastoma cell lines [BE(2)-C and SH-SY5Y] that endogenously express TH, and mu and ORL1 receptors.
Gene_expression (express) of SH-SY5Y in SH-SY5Y associated with neuroblastoma and morphine
12) Confidence 0.00 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12399106 Disease Relevance 0.17 Pain Relevance 1.27

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