INT260581

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.09
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DMPK) mitochondrion (DMPK) plasma membrane (DMPK)
nucleus (DMPK) cytoplasm (DMPK)
Anatomy Link Frequency
myoblasts 1
oesophagus 1
DMPK (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 128 95.48 Very High Very High Very High
Inflammation 12 69.36 Quite High
Crohn's disease 16 52.40 Quite High
anticonvulsant 2 6.32 Low Low
Kinase C 6 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
spastic colon 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 174 100.00 Very High Very High Very High
Disease 83 98.28 Very High Very High Very High
Paratuberculosis 160 97.80 Very High Very High Very High
Targeted Disruption 28 88.72 High High
Muscle Disease 55 86.68 High High
Hypopituitarism 45 86.16 High High
Bacterial Infection 2 85.52 High High
Autoimmune Disease 2 82.16 Quite High
Toxicity 8 79.28 Quite High
Congenital Anomalies 5 76.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The majority of symptoms associated with DM1 are thought to result from the aberrant splicing of downstream target genes [1].
DM1 Binding (associated) of
1) Confidence 0.43 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2874217 Disease Relevance 1.14 Pain Relevance 0
In DM1, MBNL1 binds to and is sequestered into nuclear foci by the mutant DMPK transcripts [14, 15].
DM1 Binding (binds) of
2) Confidence 0.32 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2874217 Disease Relevance 0.54 Pain Relevance 0
Dypshagia is a common clinical finding in DM1 patients, which is reflected by a substantial dilatation of the oesophagus that can be easily detected and rated on MRI (Fig. 2).
DM1 Spec (finding) Binding (finding) of in oesophagus associated with imagery
3) Confidence 0.25 Published 2010 Journal Eur Radiol Section Body Doc Link PMC2940021 Disease Relevance 0.30 Pain Relevance 0.25
[93] and Mef2A [70] in differentiating cells by interacting with translation initiation factor eIF2, the mechanism by which translation was inefficient in DM1 muscle cells was not fully understood, in particular after confirming that the levels of CUG-BP1 mRNA did not show any significant change in DM1 muscle cells when compared to normal myoblasts [94].
DM1 Binding (interacting) of in myoblasts
4) Confidence 0.22 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0 Pain Relevance 0
DM1 has been also associated with overexpression of the cardiac-specific transcription factor NK2 transcription factor related, locus 5 (Drosophila) (Nkx2-5), also known in Drosophila as tinman.
DM1 Binding (associated) of
5) Confidence 0.22 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.39 Pain Relevance 0
Moreover, when native M13 phage was used to investigate if the phage alone was recognized in T1DM, T2DM and controls, no statistically-significant results were found.
T1DM Neg (no) Binding (recognized) of associated with diabetes mellitus
6) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2636876 Disease Relevance 1.49 Pain Relevance 0.03
Its association with type-1 diabetes mellitus (T1DM) has been recently proposed.
T1DM Binding (association) of associated with diabetes mellitus
7) Confidence 0.00 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2636876 Disease Relevance 1.23 Pain Relevance 0

General Comments

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