INT26061

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Context Info
Confidence 0.13
First Reported 1989
Last Reported 2007
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 3
Disease Relevance 1.28
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (SH3BP5) mitochondrion (SH3BP5) intracellular (SH3BP5)
cytoplasm (SH3BP5)
Anatomy Link Frequency
SH-SY5Y 6
SH3BP5 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 12 100.00 Very High Very High Very High
Neurotransmitter 2 97.60 Very High Very High Very High
vanilloid receptor subtype 1 2 93.72 High High
Opioid 1 90.68 High High
Endocannabinoid 2 89.44 High High
Potency 2 85.12 High High
Dopamine 2 74.00 Quite High
antagonist 4 61.72 Quite High
noradrenaline 4 54.48 Quite High
Disease Link Frequency Relevance Heat
Neuroblastoma 8 100.00 Very High Very High Very High
Rheumatoid Arthritis 5 99.32 Very High Very High Very High
Death 2 95.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SH-SY5Y human neuroblastoma cells were stably transfected with hTRPV1 using the Amaxa Biosystem (hTRPV1 in pIREShyg2 with hygromycin selection).
Positive_regulation (transfected) of Gene_expression (transfected) of SH-SY5Y in SH-SY5Y associated with neuroblastoma
1) Confidence 0.13 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17442052 Disease Relevance 0.25 Pain Relevance 0.44
Activation of recombinant human TRPV1 receptors expressed in SH-SY5Y human neuroblastoma cells increases [Ca(2+)](i), initiates neurotransmitter release and promotes delayed cell death.
Positive_regulation (Activation) of Gene_expression (expressed) of SH-SY5Y in SH-SY5Y associated with neuroblastoma, neurotransmitter, qutenza and death
2) Confidence 0.09 Published 2007 Journal J. Neurochem. Section Title Doc Link 17442052 Disease Relevance 0.28 Pain Relevance 0.71
Retinoic acid enhances VIP receptor expression and responsiveness in human neuroblastoma cell, SH-SY5Y.
Positive_regulation (enhances) of Gene_expression (expression) of SH-SY5Y in SH-SY5Y associated with neuroblastoma
3) Confidence 0.04 Published 1989 Journal FEBS Lett. Section Title Doc Link 2546814 Disease Relevance 0.75 Pain Relevance 0.09

General Comments

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