INT26069

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Context Info
Confidence 0.50
First Reported 1989
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 26
Total Number 29
Disease Relevance 16.61
Pain Relevance 4.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
nucleus 4
T-cell 4
nasal 2
microglial cells 2
blood cells 2
IFNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 463 100.00 Very High Very High Very High
Multiple sclerosis 90 99.74 Very High Very High Very High
Infliximab 104 99.56 Very High Very High Very High
rheumatoid arthritis 330 99.48 Very High Very High Very High
chemokine 84 97.68 Very High Very High Very High
agonist 52 97.52 Very High Very High Very High
metalloproteinase 89 95.76 Very High Very High Very High
dexamethasone 8 95.44 Very High Very High Very High
Inflammation 468 94.44 High High
antagonist 61 88.24 High High
Disease Link Frequency Relevance Heat
Respiratory Syncytial Virus 118 99.82 Very High Very High Very High
Demyelinating Disease 73 99.74 Very High Very High Very High
Infection 612 99.70 Very High Very High Very High
Rhinitis 11 99.64 Very High Very High Very High
Hepatitis C Virus Infection 205 99.50 Very High Very High Very High
Rheumatoid Arthritis 333 99.48 Very High Very High Very High
Opiate Addiction 79 99.26 Very High Very High Very High
Fibrosis 49 99.10 Very High Very High Very High
Disease 268 97.40 Very High Very High Very High
Influenza Virus Infection 208 97.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum IFN was undetectable after single doses of 1 x 10(6) to 18 x 10(6) IU, but 60 x 10(6) IU resulted in measurable levels of circulating IFN in 3 out of 6 patients.
Positive_regulation (resulted) of Positive_regulation (levels) of IFN
1) Confidence 0.50 Published 1989 Journal J. Interferon Res. Section Abstract Doc Link 2546997 Disease Relevance 0.32 Pain Relevance 0.08
With high-dose, high-frequency interferon (IFN)-beta1a (Rebif) these AEs are generally mild but may lead to the discontinuation of some patients.
Positive_regulation (high-frequency) of Spec (may) Positive_regulation (lead) of IFN
2) Confidence 0.49 Published 2007 Journal Int J Clin Pharmacol Ther Section Abstract Doc Link 17595888 Disease Relevance 0 Pain Relevance 0
with increasing concentrations of IFN-?
Positive_regulation (increasing) of Positive_regulation (concentrations) of IFN
3) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888198 Disease Relevance 0.53 Pain Relevance 0.88
It leads to activation of the interferon-regulated factors (IRF) family of transcription factors via recruitment of TRIF and results in the synthesis of interferon (IFN).
Positive_regulation (leads) of Positive_regulation (activation) of interferon
4) Confidence 0.19 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.09 Pain Relevance 0.12
In addition, Haddad and colleagues reported that activated whole blood cells from RA patients produced higher levels of IL-4 and lower IFN-?
Positive_regulation (levels) of Positive_regulation (lower) of IFN in blood cells associated with rheumatoid arthritis
5) Confidence 0.17 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.98 Pain Relevance 0.51
Both act on Interferon promoter stimulator 1(IPS-1) that transmits the activation signal to IKKe and TANK-binding kinase-1 (TBK-1).
Positive_regulation (act) of Positive_regulation (stimulator) of Interferon
6) Confidence 0.15 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 0.95 Pain Relevance 0.03
Patients with MS who have an unsatisfactory response to IFN?
Positive_regulation (unsatisfactory) of Positive_regulation (response) of IFN associated with multiple sclerosis
7) Confidence 0.13 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938285 Disease Relevance 1.12 Pain Relevance 0.25
Honda and Taniguchi reported that type I IFN induction was mediated trough TLR signaling, which stimulated sequential activation of adaptors and kinases of the IRAK, IKK and TRAF families, and then leading to the activation of IRF5 and IRF7 [44], [45].
Positive_regulation (mediated) of Positive_regulation (induction) of IFN
8) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0.24 Pain Relevance 0
potentiated this effect, possibly via upregulation of IFN-?
Spec (possibly) Positive_regulation (potentiated) of Spec (possibly) Positive_regulation (upregulation) of IFN
9) Confidence 0.09 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 0.50 Pain Relevance 0.29
The IFN/STAT1 pathway mediates transduction of IFN signals into the nuclei of target cells.
Positive_regulation (mediates) of Positive_regulation (transduction) of IFN
10) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.12 Pain Relevance 0
IFN-mediated STAT1 transcriptional induction results in the transcription of several hundred genes designated the Interferon-Stimulated Genes (ISG; see [8], [31], [32] for reviews).
Positive_regulation (results) of Positive_regulation (induction) of IFN-mediated
11) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.14 Pain Relevance 0
STAT1 also is involved in anti-angiogenic mechanisms, partially through the induction of IFN?
Positive_regulation (through) of Positive_regulation (induction) of IFN
12) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.54 Pain Relevance 0
Interestingly, the treatment of children with allergic rhinitis with montelukast induces a significant decrease of nasal lavage IL-4 and IL-13 and a significant increase of IFN-?
Positive_regulation (induces) of Positive_regulation (increase) of IFN in nasal associated with rhinitis
13) Confidence 0.08 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.94 Pain Relevance 0.45
However, although IL-12-activated CD56+ T cells from the heroin users without HCV infection also produced lower levels of IFN-?
Positive_regulation (lower) of Positive_regulation (levels) of IFN in T cells associated with hepatitis c virus infection, opiate addiction and infection
14) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 2.08 Pain Relevance 0
T-cell activation and increased IFN-?
Positive_regulation (increased) of Positive_regulation (increased) of IFN in T-cell
15) Confidence 0.07 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.77 Pain Relevance 0
This sex-dependent activation of IFN-?
Positive_regulation (dependent) of Positive_regulation (activation) of IFN
16) Confidence 0.07 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 1.01 Pain Relevance 0.12
Although the anti-TNF-induced increase in IFN response activity might be an epiphenomenon related to the effect of TNF blockade, it is tempting to speculate on a role of increased IFN bioactivity in the deteriorating clinical effects.
Positive_regulation (induced) of Positive_regulation (increase) of IFN
17) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875639 Disease Relevance 0.85 Pain Relevance 0.34
Since the finding of an increased IFN response gene activity after TNF blockade was based on studies in diseases in which the clinical response to therapy was shown not to be optimal, we were interested to know whether this effect also applied to diseases that showed a good clinical response.
Positive_regulation (increased) of Positive_regulation (increased) of IFN associated with disease
18) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875639 Disease Relevance 0.78 Pain Relevance 0.36
Inhibition of iNOS expression by high concentrations of IRF-2 relative to IRF-1 has thus been proposed as a controlling mechanism in situations with high levels of IFN-?
Positive_regulation (mechanism) of Positive_regulation (levels) of IFN
19) Confidence 0.06 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.30 Pain Relevance 0
This difference could be brought about by differences in the requirement for co-stimulation with IFN-?
Positive_regulation (requirement) of Positive_regulation (stimulation) of IFN
20) Confidence 0.06 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.27 Pain Relevance 0

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