INT26073

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 9.17
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Scd1) endoplasmic reticulum (Scd1) lipid metabolic process (Scd1)
Anatomy Link Frequency
liver 2
hepatocytes 1
M-1 1
T cell 1
Scd1 (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 5 97.04 Very High Very High Very High
fibrosis 33 93.08 High High
cytokine 40 82.12 Quite High
sodium channel 78 75.00 Quite High
ischemia 12 66.56 Quite High
Action potential 1 56.40 Quite High
agonist 59 52.08 Quite High
antagonist 11 51.12 Quite High
Inflammation 87 50.00 Quite Low
Bioavailability 5 42.32 Quite Low
Disease Link Frequency Relevance Heat
Sickle Cell Anemia 165 100.00 Very High Very High Very High
Hypertension 74 99.96 Very High Very High Very High
Sprains And Strains 87 99.76 Very High Very High Very High
Fatty Liver 192 99.68 Very High Very High Very High
Injury 28 99.66 Very High Very High Very High
Pneumonia 39 99.62 Very High Very High Very High
Apoptosis 29 98.94 Very High Very High Very High
Acute Chest Syndrome 105 98.30 Very High Very High Very High
Targeted Disruption 71 95.12 Very High Very High Very High
Adhesions 40 94.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a more mechanistic fashion, recent studies have also suggested EGCG may alter food digestibility [15,36] and downregulate stearoyl-CoA desaturase (SCD1) gene expression [15], which may reduce adiposity, decrease lipid synthesis and increase liver fatty acid oxidation, as was found in SCD1 knockout mice [15,37].
Gene_expression (expression) of SCD1 in liver associated with targeted disruption and fatty liver
1) Confidence 0.70 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2276475 Disease Relevance 0.35 Pain Relevance 0
Furthermore, inhibition of SCD-1 sensitized hepatocytes to SFA-induced apoptosis, and mice fed with a high-fat diet showed increased SCD-1 expression and hepatic accumulation of MUFA.
Gene_expression (expression) of SCD-1 in hepatocytes associated with apoptosis
2) Confidence 0.54 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 1.05 Pain Relevance 0.04
Therefore, although Scd1-null mice are resistant to hepatic steatosis, they are more susceptible to liver injury while increased SCD-1 expression during NAFLD reflects a compensatory beneficial effect on increasing MUFA synthesis and storage of excessive FFAs as triglycerides.
Gene_expression (expression) of SCD-1 in liver associated with fatty liver and injury
3) Confidence 0.54 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 1.01 Pain Relevance 0.05
In addition, we found that triglyceride synthesis was abnormally activated, and the expression of genes encoding SREBP-1c and SCD-1, key proteins in the hepatic lipogenic pathway, failed to be appropriately down-regulated in fasted PGC-1??
Gene_expression (expression) of SCD-1
4) Confidence 0.50 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064854 Disease Relevance 0.13 Pain Relevance 0
ChREBP has also been shown to increase the expression of many of the fatty acid synthesis enzymes as well as SCD-1, thereby facilitating the conversion of glucose to fatty acids.
Gene_expression (expression) of SCD-1
5) Confidence 0.42 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.50 Pain Relevance 0.05
SREBP-1c regulates the expression of constellations of glycolytic and lipogenic genes, including stearoyl CoA desaturase (Scd-1) and fatty acid synthase (Fas) [Hebbachi et al., 2008; Horton et al., 2002; Reddy and Rao, 2006].
Gene_expression (expression) of Scd-1
6) Confidence 0.37 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.06 Pain Relevance 0
SREBP-1c regulates the expression of constellations of glycolytic and lipogenic genes, including stearoyl CoA desaturase (Scd-1) and fatty acid synthase (Fas) [Hebbachi et al., 2008; Horton et al., 2002; Reddy and Rao, 2006].
Gene_expression (expression) of CoA desaturase
7) Confidence 0.37 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.06 Pain Relevance 0
Multiple prospective screening studies have found roughly a third of adult patients with SCD have PH as defined by a TRV of ?
Gene_expression (have) of SCD associated with sickle cell anemia and hypertension
8) Confidence 0.18 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2948405 Disease Relevance 2.12 Pain Relevance 0
In this way, free radical generation in SCD may contribute to the propagation of vaso-occlusion.


Gene_expression (generation) of SCD associated with sickle cell anemia
9) Confidence 0.15 Published 2001 Journal Respir Res Section Body Doc Link PMC59517 Disease Relevance 0.63 Pain Relevance 0
Further work is necessary to define more clearly the oxidant/antioxidant profile of SCD patients at baseline and during VOCs, including ACS, and to examine the clinical effect of pharmacologic intervention to reduce oxidant production in SCD.
Gene_expression (production) of SCD associated with sickle cell anemia and acute chest syndrome
10) Confidence 0.15 Published 2001 Journal Respir Res Section Body Doc Link PMC59517 Disease Relevance 1.21 Pain Relevance 0
The RBC is an important source of oxygen-related radicals in SCD.
Gene_expression (source) of SCD associated with sickle cell anemia
11) Confidence 0.14 Published 2001 Journal Respir Res Section Body Doc Link PMC59517 Disease Relevance 0.82 Pain Relevance 0.03
In addition, the carrier provides not only distinct B cell-specific epitopes, but also class II T cell receptor binding sites, which are required to trigger T cell helper function, which in turn induces the differentiation of B cells into Ab-producing cells.
Gene_expression (producing) of Ab in T cell
12) Confidence 0.01 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.08 Pain Relevance 0
Towards this goal, in vitro bioreactor systems (which enable adequate growth of hybridoma-producing specific MAbs) or genetically modified bacteria and plants (which can express Ab fragments of defined specificity and affinity) will be of great help.
Gene_expression (express) of Ab
13) Confidence 0.01 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0 Pain Relevance 0.06
Another study of interest performed by Hirama’s group described the production of recombinant Ab fragments (rFabs) to the ABCD ring fragment [209].
Gene_expression (production) of Ab
14) Confidence 0.01 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0 Pain Relevance 0
For a comprehensive review on Ab production methods, the reader can refer to Harlow and Lane [215].
Gene_expression (production) of Ab
15) Confidence 0.01 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.11 Pain Relevance 0
Further, F1 (B6√óBalb/c) mice have reduced susceptibility to S. pneumonia strain EF3030 and express functional I-Ab, I-Ad, I-Eb, and I-Ed.
Gene_expression (express) of I-Ab associated with pneumonia and sprains and strains
16) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.96 Pain Relevance 0.04
The S1A5 monoclonal antibody (mAb) was of the IgMk class and S3E.2 of the IgG1k subclass with affinity constants (Ka values) of approximately 10(6) M-1.
Gene_expression (was) of mAb in M-1
17) Confidence 0.00 Published 1989 Journal J Toxicol Environ Health Section Abstract Doc Link 2547081 Disease Relevance 0.08 Pain Relevance 0.20

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox