INT260745

Context Info Confidence 0.02 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.03 Pain Relevance 0.25

nucleoplasm (Mapk1, Mapk1) mitochondrion (Mapk1, Mapk1) protein complex (Mapk1, Mapk1) cytoplasm (Mapk1, Mapk1) cytosol (Mapk1, Mapk1) signal transduction (Mapk1, Mapk1)

Mapk1 (Mus musculus) Mapk1 (Mus musculus)

Pain Term Frequency Confidence Heat Inflammation 38 88.00 Inflammatory mediators 3 84.56 cytokine 11 78.96 metalloproteinase 4 43.92 Inflammatory response 16 41.20 chemokine 4 31.40 Enkephalin 1 5.00 Neuropeptide 1 5.00 Mechanotransduction 1 5.00 Serotonin 1 5.00

Disease Term Frequency Confidence Heat Stress 11 100.00 INFLAMMATION 53 88.00 Obstructive Jaundice 5 84.20 Cholestasis 33 77.12 Infection 4 76.16 Cirrhosis 24 71.48 Bacterial Infection 1 65.24 Pressure And Volume Under Development 5 56.80 Injury 18 50.00 Jaundice 3 45.36

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the presence of extrahepatic biliary obstruction, the activation of p38, c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) considered 'stress kinases' [108] would be produced. p38 MAP kinase in particular has been suggested to regulate IL10 synthesis through activation of Sp1 transcription factor rather than through the NF?

extracellular signal-regulated kinase Regulation (regulate) of Positive_regulation (activation) of ERK associated with stress

1) Confidence 0.02 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2637833 Disease Relevance 1.03 Pain Relevance 0.25

General Comments

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