INT26078

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Context Info
Confidence 0.02
First Reported 1989
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 2.13
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
mast cells 2
ANTXRL (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 1 100.00 Very High Very High Very High
antagonist 2 99.06 Very High Very High Very High
agonist 3 98.74 Very High Very High Very High
Clonidine 2 91.52 High High
Inflammation 6 90.40 High High
cINOD 2 85.60 High High
sodium channel 2 79.88 Quite High
Pain 2 70.36 Quite High
potassium channel 1 56.64 Quite High
Action potential 1 49.84 Quite Low
Disease Link Frequency Relevance Heat
Bordatella Infection 3 100.00 Very High Very High Very High
Myasthenia Gravis 1 99.76 Very High Very High Very High
Hypoglycemia 1 99.24 Very High Very High Very High
INFLAMMATION 8 90.40 High High
Immunization 1 89.84 High High
Diplopia 6 80.80 Quite High
Paresis 2 80.00 Quite High
Eye Manifestations 1 77.52 Quite High
Ocular Toxicity (including Many Sub-types) 2 75.00 Quite High
Pressure And Volume Under Development 1 70.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recall that all toxin-like proteins are expected to be secreted.
Localization (secreted) of toxin-like
1) Confidence 0.02 Published 2010 Journal Bioinformatics Section Body Doc Link PMC2935411 Disease Relevance 0.20 Pain Relevance 0.03
Moreover, promutoxin was found to induce histamine release from human colon, lung and tonsil mast cells, and both metabolic inhibitors and pertussis toxin were capable of inhibiting promutoxin elicited histamine release.
Localization (release) of pertussis toxin in mast cells associated with bordatella infection
2) Confidence 0.01 Published 2010 Journal Toxicon Section Abstract Doc Link 20036273 Disease Relevance 0.33 Pain Relevance 0.20
Moreover, promutoxin was found to induce histamine release from human colon, lung and tonsil mast cells, and both metabolic inhibitors and pertussis toxin were capable of inhibiting promutoxin elicited histamine release.
Localization (release) of pertussis toxin in mast cells associated with bordatella infection
3) Confidence 0.01 Published 2010 Journal Toxicon Section Abstract Doc Link 20036273 Disease Relevance 0.34 Pain Relevance 0.20
The beta-toxin inhibits acetylcholine release by disrupting the presynaptic membrane, and thus, its effects cannot be blocked by the anticholinesterase edrophonium chloride.
Localization (release) of beta-toxin
4) Confidence 0.01 Published 2010 Journal Brain Nerve Section Abstract Doc Link 20297733 Disease Relevance 0.97 Pain Relevance 0.07
To clarify the action mechanism(s) of these agents, we investigated the effects of alpha 2 agonists and antagonists (10(-10) to 10(-4) mol/L) and pretreatment by pertussis toxin (PTX) on glucose-stimulated insulin secretion using the hamster insulinoma cell line HIT-T15.
Localization (secretion) of pertussis toxin associated with hypoglycemia, bordatella infection, antagonist and agonist
5) Confidence 0.01 Published 1997 Journal Metab. Clin. Exp. Section Abstract Doc Link 9322797 Disease Relevance 0.20 Pain Relevance 0.32
These hybrids, termed S1A5 and S3E.2, secreted specific anti-STX antibodies that did not recognize the closely related toxin tetrodotoxin (TDT), as determined by competition ELISA.
Spec (determined) Localization (secreted) of toxin tetrodotoxin associated with tetrodotoxin
6) Confidence 0.00 Published 1989 Journal J Toxicol Environ Health Section Abstract Doc Link 2547081 Disease Relevance 0.09 Pain Relevance 0.18

General Comments

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