INT260795

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Context Info
Confidence 0.33
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 11.12
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Chkb) cytoplasm (Chkb)
Anatomy Link Frequency
myocardium 4
muscle 1
Chkb (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 235 98.76 Very High Very High Very High
anesthesia 2 81.60 Quite High
ketamine 1 81.16 Quite High
isoflurane 5 63.12 Quite High
halothane 2 53.36 Quite High
Piles 1 49.92 Quite Low
Buprenorphine 2 33.36 Quite Low
Catecholamine 8 25.56 Quite Low
Inflammation 20 25.04 Quite Low
Opioid 8 24.92 Low Low
Disease Link Frequency Relevance Heat
Injury 193 99.96 Very High Very High Very High
Necrosis 73 99.60 Very High Very High Very High
Death 52 99.60 Very High Very High Very High
Apoptosis 135 99.08 Very High Very High Very High
Cv Unclassified Under Development 218 98.76 Very High Very High Very High
Targeted Disruption 102 98.70 Very High Very High Very High
Myocardial Infarction 94 97.24 Very High Very High Very High
Muscular Dystrophy 151 85.44 High High
Duchenne Muscular Dystrophy 20 84.80 Quite High
Exsanguination 2 80.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CK determination
Localization (determination) of CK
1) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888587 Disease Relevance 0 Pain Relevance 0
In some experiments, reperfusion was continued for 24 hours and injury was assessed by mitochondrial function rather than CK release.
Localization (release) of CK associated with injury
2) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816997 Disease Relevance 0.41 Pain Relevance 0.32
We found an inverse correlation between the serum levels of TRAIL, measured within 24 hours after admission, and both CK (R?
Localization (measured) of CK
3) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2637972 Disease Relevance 0.56 Pain Relevance 0
The increased permeability of the sarcolemma and the degradation of muscle proteins also results in the release of intracellular muscle proteins from the myofibre, such as creatine kinase (CK).
Localization (release) of CK in muscle
4) Confidence 0.15 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024556 Disease Relevance 0.59 Pain Relevance 0
Figures 1a-c show that, in the rat myocardium, the selective inhibition of nNOS by TRIM resulted in a significant reduction in CK release and in cell necrosis and apoptosis, as compared to the mean values in the ischemia/reoxygenation alone group.
Localization (release) of CK in myocardium associated with necrosis, ischemia and apoptosis
5) Confidence 0.14 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2927582 Disease Relevance 0.98 Pain Relevance 0.09
As seen above, again the NO donor SNAP almost abolished the CK release and the cell death induced by ischemia and reoxygenation.
Localization (release) of CK associated with ischemia and death
6) Confidence 0.14 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2927582 Disease Relevance 1.51 Pain Relevance 0.19
Figures 3a-c demonstrate that, as opposed to wild type mice, the myocardium of nNOS knockout mice could not be protected by the specific NOS inhibitor TRIM as the mean values for CK release and cell necrosis and apoptosis were not significantly different from muscles subjected to ischemia/reoxygenation alone.
Localization (release) of CK in myocardium associated with targeted disruption, necrosis, ischemia and apoptosis
7) Confidence 0.14 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2927582 Disease Relevance 1.35 Pain Relevance 0.11
Importantly, and in contrast with wild type mice, the myocardium of nNOS knockout out mice could not be protected by IP since the mean values for CK release and cell necrosis and apoptosis did not differ from the values in the ischemia/reoxygenation alone group.
Localization (release) of CK in myocardium associated with targeted disruption, necrosis, ischemia and apoptosis
8) Confidence 0.14 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2927582 Disease Relevance 1.62 Pain Relevance 0.18
Myocardial injury was assessed by measurement of creatine kinase (CK) release into the media during the 120 min reoxygenation period.
Localization (release) of CK associated with injury
9) Confidence 0.14 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2927582 Disease Relevance 0.68 Pain Relevance 0.21
Figures 4a-c demonstrate that the reduction in CK release and in cell necrosis and apoptosis caused by the NO donor SNAP and the inhibition of nNOS with TRIM, was unaffected by the mitoKATP channel blocker 5-HD, and that, as expected, it blocked the protection by IP.
Localization (release) of CK associated with necrosis and apoptosis
10) Confidence 0.12 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2927582 Disease Relevance 1.34 Pain Relevance 0.16
It is also interesting to note that myocardial injury (CK release and cell death) was not increased by ischemia/reoxygenation in nNOS knockout mice, a finding supported by the absence of changes in infarct size in nNOS knockout mice [9,11].
Localization (release) of CK associated with targeted disruption, ischemia, injury and death
11) Confidence 0.12 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2927582 Disease Relevance 0.96 Pain Relevance 0.17
As seen in Figures 2a-f, and in comparison with the results observed in Figures 1a-c, the order of magnitude of ischemic injury for CK release and cell necrosis and apoptosis varied slightly between species, however, identical effects on NOS inhibition and from the administration of exogenous NO to that seen in rat myocardium (Figures 1a-c) were observed for both mouse and human myocardium.


Localization (release) of CK in myocardium associated with necrosis, injury and apoptosis
12) Confidence 0.12 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2927582 Disease Relevance 1.14 Pain Relevance 0.10

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