INT260819

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Context Info
Confidence 0.12
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 0.66
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (OSM) extracellular space (OSM) extracellular region (OSM)
Anatomy Link Frequency
monocyte 1
OSM (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 16 62.16 Quite High
Inflammation 32 50.00 Quite Low
Inflammatory mediators 6 27.00 Quite Low
chemokine 18 5.00 Very Low Very Low Very Low
Central nervous system 12 5.00 Very Low Very Low Very Low
Glutamate 12 5.00 Very Low Very Low Very Low
imagery 12 5.00 Very Low Very Low Very Low
withdrawal 6 5.00 Very Low Very Low Very Low
headache 6 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bacterial Infection 7 95.04 Very High Very High Very High
Infection 30 86.32 High High
Streptococcal Infections 1 75.60 Quite High
Peritonitis 15 71.80 Quite High
Apoptosis 57 50.20 Quite High
INFLAMMATION 40 50.00 Quite Low
Renal Failure 13 48.24 Quite Low
Stroke 12 5.00 Very Low Very Low Very Low
Metastasis 6 5.00 Very Low Very Low Very Low
Adhesions 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, TRAIL, CXCL10, and OSM) that we found prominently expressed in HMB-PP-stimulated monocyte-??
OSM Binding (found) of in monocyte
1) Confidence 0.12 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0.61 Pain Relevance 0.03
We therefore speculate that PDCD10-OSM and PDCD10-VEGFR2 interactions may be regulated by the availability of PtdIns(3,4,5)P3 generated by PI3K.
OSM Binding (interactions) of
2) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0
These lysines are also important in PDCD10-OSM interaction.
OSM Binding (interaction) of
3) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0
Examination of phospholipid and OSM binding using recombinant PDCD10 proteins
OSM Binding (binding) of
4) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0
Interestingly, these pull-down experiments showed that the mutant fails to interact with OSM.
OSM Binding (interact) of
5) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0
5KA does not bind OSM.
OSM Neg (not) Binding (bind) of
6) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0.05 Pain Relevance 0
OSM interaction with ?
OSM Binding (interaction) of
7) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

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