INT260823

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Context Info
Confidence 0.19
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.14
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Nrp1) cytosol (Nrp1) cell adhesion (Nrp1)
plasma membrane (Nrp1)
Anatomy Link Frequency
endothelial cells 3
growth cone 2
leukocytes 1
Nrp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 49 99.74 Very High Very High Very High
rheumatoid arthritis 114 99.20 Very High Very High Very High
Inflammation 53 62.64 Quite High
Arthritis 16 50.00 Quite Low
Osteoarthritis 6 32.08 Quite Low
cytokine 6 26.00 Quite Low
Antinociceptive 1 19.72 Low Low
Pain 1 9.08 Low Low
antagonist 11 5.00 Very Low Very Low Very Low
substance P 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Eczema 108 99.48 Very High Very High Very High
Rheumatoid Arthritis 116 99.20 Very High Very High Very High
Shock 1 96.88 Very High Very High Very High
Breast Cancer 4 91.76 High High
Apoptosis 8 83.12 Quite High
Pruritus 24 79.12 Quite High
Acanthosis 2 68.64 Quite High
INFLAMMATION 57 62.64 Quite High
Skin Diseases 3 46.16 Quite Low
Fibromyalgia 2 45.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the combination therapy of Sema3A with anti-NGF antibody may not be justified for AD, because NGF is known to increase the expression levels of NRP-157 and to augment the effect of Sema3A to induce axon repulsion (or growth cone collapse) of dorsal root ganglia neurons.58 Further studies should be required to elucidate the mechanism of action of Sema3A on AD.
Positive_regulation (increase) of Gene_expression (expression) of NRP-157 in growth cone associated with nerve growth factor, shock and eczema
1) Confidence 0.19 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946701 Disease Relevance 0.93 Pain Relevance 0.22
NP-1 was found to be highly expressed in the lining layer, and on infiltrating leukocytes and endothelial cells of the rheumatoid synovium.
Positive_regulation (highly) of Gene_expression (expressed) of NP-1 in endothelial cells
2) Confidence 0.14 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2638142 Disease Relevance 0.61 Pain Relevance 0.22
NP-1 was found to be highly expressed in the lining layer, and on infiltrating leukocytes and endothelial cells of the rheumatoid synovium.
Positive_regulation (highly) of in leukocytes Gene_expression (expressed) of NP-1 in endothelial cells
3) Confidence 0.05 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2638142 Disease Relevance 0.61 Pain Relevance 0.22

General Comments

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