INT260838

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.67
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il17a, VEGFA) extracellular region (Il17a, VEGFA) growth (VEGFA)
proteinaceous extracellular matrix (VEGFA) cytoplasm (VEGFA)
Anatomy Link Frequency
fibroblasts 2
Il17a (Mus musculus)
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 57 98.98 Very High Very High Very High
Osteoarthritis 3 88.40 High High
Arthritis 8 85.52 High High
Inflammation 23 74.80 Quite High
Inflammatory mediators 1 68.56 Quite High
Inflammatory response 2 45.52 Quite Low
anakinra 1 17.32 Low Low
abatacept 1 16.76 Low Low
antagonist 5 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 2 100.00 Very High Very High Very High
Rheumatoid Arthritis 58 98.98 Very High Very High Very High
Targeted Disruption 2 93.04 High High
Disease 10 91.16 High High
Osteoarthritis 3 88.40 High High
Arthritis 8 85.52 High High
Nicotine Addiction 2 84.28 Quite High
INFLAMMATION 26 74.80 Quite High
Pressure And Volume Under Development 1 74.24 Quite High
Solid Tumor 2 73.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VEGF protein and mRNA are expressed by synovial macrophages and synovial fibroblasts in the synovial tissues of RA patients, and cultured synovial cells are able to secrete VEGF under hypoxic conditions or when stimulated with IL-1, IL-6, IL-17, IL-18, -prostaglandin, or TGF-?
IL-17 Positive_regulation (stimulated) of Localization (secrete) of VEGF in fibroblasts associated with hypoxia and rheumatoid arthritis
1) Confidence 0.06 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2638142 Disease Relevance 1.67 Pain Relevance 0.47

General Comments

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