INT260841

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.70
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NRP2) extracellular space (Il6) extracellular region (Il6)
cell adhesion (NRP2) plasma membrane (NRP2)
Anatomy Link Frequency
endothelial cells 2
Il6 (Mus musculus)
NRP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 2 86.72 High High
rheumatoid arthritis 57 80.16 Quite High
Inflammation 23 76.68 Quite High
Arthritis 8 50.00 Quite Low
Inflammatory response 2 45.68 Quite Low
Inflammatory mediators 1 34.20 Quite Low
Osteoarthritis 3 5.04 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
abatacept 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 1 83.08 Quite High
Rheumatoid Arthritis 58 80.16 Quite High
INFLAMMATION 26 76.68 Quite High
Cancer 10 69.28 Quite High
Apoptosis 4 51.36 Quite High
Starvation 1 49.20 Quite Low
Targeted Disruption 2 40.76 Quite Low
Arthritis 8 25.20 Quite Low
Hypoxia 2 15.48 Low Low
Disease 10 5.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
and IL-6, in turn, further enhance the capacities of macrophages and synoviocytes to secrete VEGF165, and stimulate endothelial cells to induce cell-contact-mediated macrophage activation, which generates a positive feedback-loop (Figure 1).
IL-6 Positive_regulation (enhance) of Localization (secrete) of VEGF165 in endothelial cells
1) Confidence 0.00 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2638142 Disease Relevance 0.70 Pain Relevance 0.29

General Comments

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