INT260842

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.28
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (NRP2, Kdr) cell differentiation (NRP2) cell adhesion (NRP2)
kinase activity (Kdr) cytoplasm (Kdr)
Anatomy Link Frequency
synovium 1
NRP2 (Homo sapiens)
Kdr (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 114 99.96 Very High Very High Very High
Inflammation 46 99.64 Very High Very High Very High
cytokine 4 93.72 High High
Osteoarthritis 6 89.84 High High
Arthritis 16 50.00 Quite Low
chemokine 4 20.28 Low Low
antagonist 10 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
abatacept 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibromyalgia 2 100.00 Very High Very High Very High
Rheumatoid Arthritis 116 99.96 Very High Very High Very High
INFLAMMATION 52 99.64 Very High Very High Very High
Hyperplasia 12 92.84 High High
Osteoarthritis 6 89.84 High High
Disease 20 85.44 High High
Apoptosis 8 65.16 Quite High
Starvation 2 63.20 Quite High
Cancer 20 52.96 Quite High
Breast Cancer 4 46.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
First, VEGF165 binding to KDR may lead to an increase in angiogenesis, and thereby, the recruitment of peripheral leukocytes to inflamed synovium, which diminishes the growing burden of synoviocytes by supplying the oxygen and nutrients required for tissue metabolism.
VEGF165 Binding (binding) of KDR in synovium
1) Confidence 0.00 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2638142 Disease Relevance 1.12 Pain Relevance 0.50
VEGF165 exerts its biological effects by binding with its receptor subtypes, that is, fms-like tyrosine kinase (Flt-1), kinase insert domain-containing receptor (KDR) and neuropilin-1 (NP-1) [3].
VEGF165 Binding (binding) of KDR associated with fibromyalgia
2) Confidence 0.00 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2638142 Disease Relevance 1.16 Pain Relevance 0.35

General Comments

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