INT260853

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.82
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Grip2) plasma membrane (Grip2) cytoskeleton (Grip2)
cytoplasm (Grip2)
Anatomy Link Frequency
nerve 2
hippocampus 2
Grip2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 71 99.68 Very High Very High Very High
nMDA receptor 137 97.30 Very High Very High Very High
long-term potentiation 32 94.96 High High
Peripheral nerve injury 3 74.32 Quite High
Somatosensory cortex 5 57.56 Quite High
projection neuron 1 53.04 Quite High
Glutamate 24 45.20 Quite Low
Glutamate receptor 8 39.60 Quite Low
agonist 13 30.32 Quite Low
antagonist 20 28.00 Quite Low
Disease Link Frequency Relevance Heat
Nervous System Injury 12 99.64 Very High Very High Very High
Sprains And Strains 7 92.36 High High
Aging 114 86.64 High High
Injury 2 50.00 Quite Low
Cognitive Disorder 25 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 14 5.00 Very Low Very Low Very Low
Depression 10 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low
Carpal Tunnel Syndrome 4 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Most notably, we have reported an increase in AMPA receptor autoradiographic binding at post-nerve injury survival durations when the putative second phase of reorganization has been completed (Garraghty et al., 2006), but this was not seen at early (i.e., 0–3?
Positive_regulation (increase) of AMPA receptor Binding (binding) of in nerve associated with nervous system injury
1) Confidence 0.02 Published 2008 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2638550 Disease Relevance 0.32 Pain Relevance 0.29
In Long-Evans rats, NMDA receptor binding is more decreased in certain regions than either AMPA or kainate binding (Nicolle et al., 1996; Nicolle and Baxter, 2003) and AMPA binding was significantly increased in the hippocampus in aged rats that were impaired in spatial learning as compared to young (Le Jeune et al., 1996; Andres et al., 2000).
Positive_regulation (increased) of AMPA Binding (binding) of in hippocampus associated with nmda receptor and hippocampus
2) Confidence 0.01 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.51 Pain Relevance 0.38

General Comments

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