INT260854

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.10
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.06
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gabrd)
Anatomy Link Frequency
cortex 2
Gabrd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Potency 7 85.84 High High
agonist 1 67.84 Quite High
nMDA receptor 8 66.08 Quite High
long-term potentiation 6 49.60 Quite Low
Hippocampus 2 46.72 Quite Low
Somatosensory cortex 5 7.04 Low Low
gABA 7 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Peripheral nerve injury 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nervous System Injury 12 55.68 Quite High
Injury 2 50.00 Quite Low
Carpal Tunnel Syndrome 4 5.00 Very Low Very Low Very Low
Respiratory Failure 1 5.00 Very Low Very Low Very Low
Aids-related Complex 1 5.00 Very Low Very Low Very Low
Sleep Disorders 1 5.00 Very Low Very Low Very Low
Heart Rate Under Development 1 5.00 Very Low Very Low Very Low
Anxiety Disorder 1 5.00 Very Low Very Low Very Low
Critical Illness 1 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alternatively, the ability of high concentration 1 to block the GABAA complex (Figure 5) may indicate the recruitment of additional, low affinity sites within this ion channel because of the electrophysiological signature for channel blockade at high (lethal) concentrations.
Negative_regulation (block) of GABAA Binding (complex) of
1) Confidence 0.10 Published 2010 Journal Journal of Medicinal Chemistry Section Body Doc Link PMC2917171 Disease Relevance 0 Pain Relevance 0.16
The immediate plasticity is assumed to reflect the unmasking of tonically suppressed inputs due to a relaxation in afferent-driven inhibition, and we have reported reductions in GABAA receptor binding in layer IV of deprived area 3b cortex within hours of nerve transection (Garraghty et al., 2006; Wellman et al., 2002), a finding that is consistent with a down-regulation of inhibition.
Negative_regulation (reductions) of GABAA receptor Spec (finding) Binding (binding) of in cortex
2) Confidence 0.01 Published 2008 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2638550 Disease Relevance 0.06 Pain Relevance 0.06

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox