INT260858

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.77
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6, VEGFA) extracellular region (IL6, VEGFA) growth (VEGFA)
aging (IL6) proteinaceous extracellular matrix (VEGFA) cytoplasm (VEGFA)
IL6 (Homo sapiens)
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 78 94.44 High High
rheumatoid arthritis 23 93.16 High High
Inflammation 45 86.12 High High
methotrexate 43 62.44 Quite High
COX-2 inhibitor 23 42.76 Quite Low
chemokine 20 23.20 Low Low
metalloproteinase 102 5.00 Very Low Very Low Very Low
cINOD 7 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 15 99.64 Very High Very High Very High
Adhesions 42 96.32 Very High Very High Very High
Rheumatoid Arthritis 23 93.16 High High
Infection 108 91.84 High High
Herpes Simplex Virus 238 89.68 High High
INFLAMMATION 50 86.12 High High
Latent Tuberculosis 1 83.36 Quite High
Mycobacterial Infection 4 69.04 Quite High
Sarcoma 79 67.04 Quite High
Disorder Of Lipid Metabolism 6 64.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The normalization of VEGF by blockade of IL-6 function alone indicates that IL-6 is essential for the VEGF production in this disease.
IL-6 Positive_regulation (essential) of Gene_expression (production) of VEGF associated with disease
1) Confidence 0.31 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2638601 Disease Relevance 1.03 Pain Relevance 0.32
and IL-6 which are known to up-regulate VEGF expression.
IL-6 Positive_regulation (up-regulate) of Gene_expression (expression) of VEGF
2) Confidence 0.04 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.74 Pain Relevance 0.16

General Comments

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