INT260876

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Context Info
Confidence 0.29
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.47
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL7R) extracellular region (IL7R) cell morphogenesis (IL7R)
plasma membrane (IL7R)
IL7R (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 50 98.20 Very High Very High Very High
Inflammation 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Demyelination 1 5.00 Very Low Very Low Very Low
Neuritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 56 98.20 Very High Very High Very High
Mental Disorders 1 29.36 Quite Low
Disease 45 5.00 Very Low Very Low Very Low
Recurrence 6 5.00 Very Low Very Low Very Low
Autoimmune Disease 3 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Neuromyelitis Optica 1 5.00 Very Low Very Low Very Low
Optic Atrophy 1 5.00 Very Low Very Low Very Low
Optic Neuritis 1 5.00 Very Low Very Low Very Low
Optic Disorders 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quite why impaired IL7R signalling increases the risk of developing multiple sclerosis remains unknown, and of course it is always possible that the effect of this variant on IL7 signalling is an epiphenomenon with some other as yet untested function of this gene being more relevant to susceptibility.
Negative_regulation (impaired) of IL7R associated with multiple sclerosis
1) Confidence 0.29 Published 2008 Journal Brain Section Body Doc Link PMC2639203 Disease Relevance 0.47 Pain Relevance 0.24

General Comments

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