INT260897

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.09
Pain Relevance 1.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CRH, IL8) extracellular space (CRH, IL8) extracellular region (CRH, IL8)
intracellular (IL8) response to stress (CRH)
Anatomy Link Frequency
fibroblasts 6
CRH (Homo sapiens)
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 294 98.28 Very High Very High Very High
Inflammation 9 88.96 High High
cytokine 18 83.52 Quite High
Dismenorea 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 9 88.96 High High
Pre-term Labor 21 48.40 Quite Low
Premature Birth 18 17.32 Low Low
Dysmenorrhea 3 5.00 Very Low Very Low Very Low
Diabetes Mellitus 3 5.00 Very Low Very Low Very Low
Asphyxia 3 5.00 Very Low Very Low Very Low
Emergencies 3 5.00 Very Low Very Low Very Low
Abruptio Placentae 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Breech Presentation 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CRH significantly increased the secretion of IL-8 from the term and preterm cervical fibroblasts at concentrations 10?
CRH Positive_regulation (increased) of Localization (secretion) of IL-8 in fibroblasts
1) Confidence 0.24 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639405 Disease Relevance 0 Pain Relevance 0.83
Furthermore, CRH stimulates the secretion of IL-8 both in preterm and term cervical fibroblasts, which suggests that CRH could be involved in the process of cervical ripening.
CRH Positive_regulation (stimulates) of Localization (secretion) of IL-8 in fibroblasts
2) Confidence 0.18 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639405 Disease Relevance 0 Pain Relevance 0.23
We have shown that CRH increased the secretion of IL-8 in both preterm and term cervical fibroblasts, but did not affect the secretion of MMP-1 and MMP-3.
CRH Neg (not) Positive_regulation (increased) of Localization (secretion) of IL-8 in fibroblasts associated with metalloproteinase
3) Confidence 0.18 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639405 Disease Relevance 0.09 Pain Relevance 0.45

General Comments

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