INT2609

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Context Info
Confidence 0.81
First Reported 1979
Last Reported 2011
Negated 4
Speculated 1
Reported most in Abstract
Documents 111
Total Number 112
Disease Relevance 50.22
Pain Relevance 26.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ELANE) extracellular region (ELANE) cytoplasm (ELANE)
Anatomy Link Frequency
neutrophils 32
leukocytes 9
granulocyte 5
blood 4
liver 4
ELANE (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 828 100.00 Very High Very High Very High
Morphine 824 100.00 Very High Very High Very High
rheumatoid arthritis 249 100.00 Very High Very High Very High
Dopamine 96 100.00 Very High Very High Very High
cINOD 77 99.92 Very High Very High Very High
Angina 58 99.84 Very High Very High Very High
acular 7 99.78 Very High Very High Very High
qutenza 27 99.60 Very High Very High Very High
Nicotine 100 99.40 Very High Very High Very High
Acupuncture 126 99.38 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 946 100.00 Very High Very High Very High
Rheumatoid Arthritis 251 100.00 Very High Very High Very High
Infection 191 99.92 Very High Very High Very High
Colitis 25 99.88 Very High Very High Very High
Cv General 3 Under Development 69 99.84 Very High Very High Very High
Stress 620 99.56 Very High Very High Very High
Pyelonephritis 12 99.44 Very High Very High Very High
Cancer 84 99.24 Very High Very High Very High
Sepsis 284 99.12 Very High Very High Very High
Prostatitis 42 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased neutrophil elastase release in unstable angina pectoris and acute myocardial infarction.
Localization (release) of neutrophil elastase in neutrophil associated with angina and myocardial infarction
1) Confidence 0.81 Published 1990 Journal J. Am. Coll. Cardiol. Section Title Doc Link 2345235 Disease Relevance 1.12 Pain Relevance 0.63
The secretion of elastase from neutrophils into BALF was stimulated during the course of general anesthesia.
Localization (secretion) of elastase in neutrophils associated with anesthesia
2) Confidence 0.80 Published 2006 Journal Transl Res Section Abstract Doc Link 16890150 Disease Relevance 0.22 Pain Relevance 0.44
To characterize neutrophil function in ischemic heart disease, neutrophil chemotaxis, leukotriene B4 (LTB4) generation, and elastase release in plasma were measured in 20 patients with stable angina, 17 patients with unstable angina or acute myocardial infarction (AMI), and 20 age-matched control subjects.
Localization (release) of elastase in neutrophil associated with angina, coronary artery disease and myocardial infarction
3) Confidence 0.79 Published 1989 Journal Circulation Section Abstract Doc Link 2537159 Disease Relevance 1.05 Pain Relevance 0.39
The effect of some anti-inflammatory agents on elastase release from neutrophils in-vitro.
Localization (release) of elastase in neutrophils associated with inflammation
4) Confidence 0.76 Published 1990 Journal J. Pharm. Pharmacol. Section Title Doc Link 1980289 Disease Relevance 0.27 Pain Relevance 0.22
Elastase release from neutrophils exposed to the synthetic bacterial cell wall peptide N-formyl-L-methionyl-L-leucyl-L-phenylalanine (10(-6) M) was quantitated using a radiometric immunoassay and a functional assay of elastase.
Localization (release) of Elastase in neutrophils
5) Confidence 0.76 Published 1990 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 1980289 Disease Relevance 0.25 Pain Relevance 0.22
In view of the potential role of released polymorphonuclear leucocyte elastase in causing tissue damage, the effect of commonly used anti-inflammatory drugs on elastase release from neutrophils has been studied in-vitro.
Localization (release) of elastase in polymorphonuclear leucocyte associated with inflammation and cinod
6) Confidence 0.76 Published 1990 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 1980289 Disease Relevance 0.25 Pain Relevance 0.21
In the experiment in which pancreatic juice and pig pancreatic kallikrein were added to granulocytes in vitro, we recognized a gradual release of PMN-elastase.
Localization (release) of PMN-elastase in PMN
7) Confidence 0.76 Published 1992 Journal Agents Actions Suppl. Section Abstract Doc Link 1462874 Disease Relevance 0.41 Pain Relevance 0.08
The anti-asthmatic/anti-allergic compounds azelastine, astemizole and oxatomide, and the 5-lipoxygenase inhibitor NDGA, were able to suppress the release of elastase from human leukocytes in concentrations between 10 and 100 microM.
Localization (release) of elastase in leukocytes associated with asthma and hypersensitivity
8) Confidence 0.73 Published 1993 Journal Agents Actions Section Abstract Doc Link 8100381 Disease Relevance 0.62 Pain Relevance 0.41
To test our hypothesis that extracellular elastase release during acute pyelonephritis may contribute to subsequent renal parenchymal damage, we compared the intracellular and extracellular activities of the lysozyme elastase of human polymorphonuclear cells (PMN) when incubated in vitro with bacterial strains causing renal infection that led to either renal damage or no damage.
Localization (release) of elastase associated with sprains and strains, pyelonephritis and infection
9) Confidence 0.70 Published 1995 Journal Pediatr. Nephrol. Section Abstract Doc Link 8580015 Disease Relevance 0.89 Pain Relevance 0.11
During acute inflammatory processes, extracellular release of granulocyte elastase can contribute to subsequent tissue damage.
Localization (release) of elastase in granulocyte associated with inflammation
10) Confidence 0.70 Published 1995 Journal Pediatr. Nephrol. Section Abstract Doc Link 8580015 Disease Relevance 0.74 Pain Relevance 0.11
In assessing the elevated NE epilepsy hypothesis, the following seven lines of evidence are examined that include studies of: (1) antidepressants that raise the level of NE; (2) clonidine and other alpha 2 adrenergic agonist drugs that lower the level of NE; (3) prazosin and other drugs that affect alpha adrenoceptors; (4) propranolol and other drugs that affect beta adrenoceptors; (5) pheochromocytoma, which is a rare cancer of the adrenal glands that can boost NE levels; (6) comorbidity of epilepsy with bipolar disorder, hypertension, and obesity, where all four conditions may involve elevated NE; and (7) psychological stress, which is associated with increased release of NE.
Localization (release) of NE in adrenal glands associated with stress, adrenal cancer, pheochromocytoma, clonidine, epilepsy, antidepressant, manic depressive disorder, obesity, agonist and hypertension
11) Confidence 0.70 Published 2010 Journal Seizure Section Abstract Doc Link 20493725 Disease Relevance 0.91 Pain Relevance 0.28
Conclusion: CS, which is a major acidic lipid in the tracheobronchial epithelium, might function as an epithelial inhibitor toward neutrophil elastase secreted in response to several stimuli such as anesthesia.
Localization (secreted) of elastase in epithelium associated with anesthesia
12) Confidence 0.70 Published 2006 Journal Transl Res Section Abstract Doc Link 16890150 Disease Relevance 0.08 Pain Relevance 0.44
Intense neutrophil activation in unstable angina or AMI, as manifested by morphologic changes in neutrophils and elastase release, may relate to ongoing in vivo cellular activation.
Localization (release) of elastase in neutrophils associated with angina and myocardial infarction
13) Confidence 0.69 Published 1989 Journal Circulation Section Abstract Doc Link 2537159 Disease Relevance 0.95 Pain Relevance 0.54
Released PMN-elastase inactivates exotoxin A, the major toxin of P. aeruginosa, thus reducing its virulence.
Localization (Released) of PMN-elastase in PMN
14) Confidence 0.69 Published 1989 Journal Acta Paediatr Scand Suppl Section Abstract Doc Link 2518396 Disease Relevance 0.60 Pain Relevance 0.20
Prednisolone and non-steroidal anti-inflammatory drugs inhibited elastase release at concentrations from 0.1 mM-0.1 nM.
Localization (release) of elastase associated with inflammation and cinod
15) Confidence 0.67 Published 1990 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 1980289 Disease Relevance 0.26 Pain Relevance 0.22
In view of the potential role of released polymorphonuclear leucocyte elastase in causing tissue damage, the effect of commonly used anti-inflammatory drugs on elastase release from neutrophils has been studied in-vitro.
Localization (released) of elastase in neutrophils associated with inflammation and cinod
16) Confidence 0.67 Published 1990 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 1980289 Disease Relevance 0.24 Pain Relevance 0.20
The activation of circulating polymorphonuclear leukocytes was determined in terms of O2.- generation and elastase release in patients with stable angina (n = 12) and in control subjects (n = 8) after maximal physical exercise and after a 15-min recovery.
Localization (release) of elastase in polymorphonuclear leukocytes associated with angina
17) Confidence 0.65 Published 1992 Journal Int. J. Cardiol. Section Abstract Doc Link 1334947 Disease Relevance 0.30 Pain Relevance 0.30
Such activation occurs without elastase release.
Localization (release) of elastase
18) Confidence 0.65 Published 1992 Journal Int. J. Cardiol. Section Abstract Doc Link 1334947 Disease Relevance 0.54 Pain Relevance 0.54
PMN elastase, secreted by PMN leukocytes, is also a sensitive indicator of inflammation [28].
Localization (secreted) of elastase in leukocytes associated with inflammation
19) Confidence 0.65 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2778713 Disease Relevance 1.25 Pain Relevance 0.56
Chronic obstructive pulmonary diseases (COPD), mucociliary clearance (MC), electro-acupuncture (EA), needle puncture (NP), human neutrophil elastase (HNE), mucociliary transport velocity (MTV), phosphate buffered saline without Ca2+ and Mg2+ (PBS (-))

Competing interests

Localization (saline) of HNE in puncture associated with pulmonary disease and acupuncture
20) Confidence 0.65 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1397865 Disease Relevance 0.62 Pain Relevance 0.34

General Comments

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