INT260901

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 10
Disease Relevance 8.78
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Elavl1) nucleus (Elavl1) cytoplasm (Elavl1)
Anatomy Link Frequency
MDA-MB-231 1
Elavl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 37 99.12 Very High Very High Very High
Inflammation 1045 98.24 Very High Very High Very High
cytokine 299 91.36 High High
Arthritis 46 60.32 Quite High
chemokine 90 5.00 Very Low Very Low Very Low
cINOD 46 5.00 Very Low Very Low Very Low
Inflammatory response 36 5.00 Very Low Very Low Very Low
Inflammatory stimuli 27 5.00 Very Low Very Low Very Low
aspirin 9 5.00 Very Low Very Low Very Low
Inflammatory mediators 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 1297 99.76 Very High Very High Very High
Breast Cancer 45 98.88 Very High Very High Very High
Stress 30 98.40 Very High Very High Very High
INFLAMMATION 1082 98.24 Very High Very High Very High
Congenital Anomalies 21 97.08 Very High Very High Very High
Ovarian Cancer 18 94.56 High High
Colon Cancer 72 84.56 Quite High
Leukemia 18 80.16 Quite High
Glioblastoma 9 73.92 Quite High
Glioma 18 73.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased cytoplasmic localization of ELAVL1 protein is associated with increased oxidative stress and enhanced MAPKAPK2/3 phosphorylation (Lal et al., 2004; Raineri et al., 2004; Cherry et al., 2006).
Localization (localization) of ELAVL1 protein associated with stress
1) Confidence 0.47 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639449 Disease Relevance 0.16 Pain Relevance 0.03
A detailed review on the role of phosphorylation in HuR translocation, see [161].


Localization (translocation) of HuR
2) Confidence 0.37 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.01 Pain Relevance 0.22
Thus, these many studies clearly show consistent correlation of cytoplasmic localization of HuR with tumor grade, tumor size, and patient survival in many types of cancer tissues.
Localization (localization) of HuR associated with cancer
3) Confidence 0.37 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.08 Pain Relevance 0.07
Aberrations in the expression or activity of these kinases in cancer can lead to changes in HuR phosphorylation that favor cytoplasmic localization of HuR.
Localization (localization) of HuR associated with cancer
4) Confidence 0.37 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.01 Pain Relevance 0.21
The p38 MAPK regulates HuR localization and subsequently HuR mRNA targets that are involved in chronic inflammation and cancer such as uPA and COX-2 [128–130].
Localization (localization) of HuR associated with inflammation and cancer
5) Confidence 0.37 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.37 Pain Relevance 0.10
How is cytoplasmic localization of HuR promoted in tumor cells?
Localization (localization) of HuR associated with cancer
6) Confidence 0.37 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.07 Pain Relevance 0.08
The overexpression of constitutively active MK2 results in increased HuR cytoplasmic localization in the MDA-MB-231 invasive breast cancer line [129].
Localization (localization) of HuR in MDA-MB-231 associated with breast cancer
7) Confidence 0.37 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.00 Pain Relevance 0.18
Overexpression and cytoplasmic localization of stabilizing ARE binding proteins, notably HuR, with commitment functional loss of RNA decay-promoting proteins such as TTP can be associated with chronic inflammation and cancer.
Localization (localization) of HuR associated with inflammation and cancer
8) Confidence 0.37 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.29 Pain Relevance 0.17
Several studies have pointed out that HuR is overexpressed in tumor cells when compared to their normal counterparts, with increased localization of HuR in cytoplasmic compartments.
Localization (localization) of HuR associated with cancer
9) Confidence 0.34 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.89 Pain Relevance 0.03
Certain signaling aberrations in cancer may promote cytoplasmic HuR localization such as p38 MAPK and PKC pathways.
Localization (localization) of HuR associated with kinase c and cancer
10) Confidence 0.32 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.90 Pain Relevance 0.09

General Comments

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