INT260901

Context Info Confidence 0.47 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 10 Disease Relevance 8.78 Pain Relevance 1.18

RNA binding (Elavl1) nucleus (Elavl1) cytoplasm (Elavl1)

Anatomy Link Frequency MDA-MB-231 1 Elavl1 (Mus musculus)

Pain Link Frequency Relevance Heat Kinase C 37 99.12 Inflammation 1045 98.24 cytokine 299 91.36 Arthritis 46 60.32 chemokine 90 5.00 cINOD 46 5.00 Inflammatory response 36 5.00 Inflammatory stimuli 27 5.00 aspirin 9 5.00 Inflammatory mediators 9 5.00

Disease Link Frequency Relevance Heat Cancer 1297 99.76 Breast Cancer 45 98.88 Stress 30 98.40 INFLAMMATION 1082 98.24 Congenital Anomalies 21 97.08 Ovarian Cancer 18 94.56 Colon Cancer 72 84.56 Leukemia 18 80.16 Glioblastoma 9 73.92 Glioma 18 73.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Increased cytoplasmic localization of ELAVL1 protein is associated with increased oxidative stress and enhanced MAPKAPK2/3 phosphorylation (Lal et al., 2004; Raineri et al., 2004; Cherry et al., 2006).

Localization (localization) of ELAVL1 protein associated with stress

1) Confidence 0.47 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639449 Disease Relevance 0.16 Pain Relevance 0.03

A detailed review on the role of phosphorylation in HuR translocation, see [161].

Localization (translocation) of HuR

2) Confidence 0.37 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.01 Pain Relevance 0.22

Thus, these many studies clearly show consistent correlation of cytoplasmic localization of HuR with tumor grade, tumor size, and patient survival in many types of cancer tissues.

Localization (localization) of HuR associated with cancer

3) Confidence 0.37 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.08 Pain Relevance 0.07

Aberrations in the expression or activity of these kinases in cancer can lead to changes in HuR phosphorylation that favor cytoplasmic localization of HuR.

Localization (localization) of HuR associated with cancer

4) Confidence 0.37 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.01 Pain Relevance 0.21

The p38 MAPK regulates HuR localization and subsequently HuR mRNA targets that are involved in chronic inflammation and cancer such as uPA and COX-2 [128–130].

Localization (localization) of HuR associated with inflammation and cancer

5) Confidence 0.37 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.37 Pain Relevance 0.10

How is cytoplasmic localization of HuR promoted in tumor cells?

Localization (localization) of HuR associated with cancer

6) Confidence 0.37 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.07 Pain Relevance 0.08

The overexpression of constitutively active MK2 results in increased HuR cytoplasmic localization in the MDA-MB-231 invasive breast cancer line [129].

Localization (localization) of HuR in MDA-MB-231 associated with breast cancer

7) Confidence 0.37 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.00 Pain Relevance 0.18

Overexpression and cytoplasmic localization of stabilizing ARE binding proteins, notably HuR, with commitment functional loss of RNA decay-promoting proteins such as TTP can be associated with chronic inflammation and cancer.

Localization (localization) of HuR associated with inflammation and cancer

8) Confidence 0.37 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.29 Pain Relevance 0.17

Several studies have pointed out that HuR is overexpressed in tumor cells when compared to their normal counterparts, with increased localization of HuR in cytoplasmic compartments.

Localization (localization) of HuR associated with cancer

9) Confidence 0.34 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.89 Pain Relevance 0.03

Certain signaling aberrations in cancer may promote cytoplasmic HuR localization such as p38 MAPK and PKC pathways.

Localization (localization) of HuR associated with kinase c and cancer

10) Confidence 0.32 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.90 Pain Relevance 0.09

General Comments

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