INT260905

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Context Info
Confidence 0.52
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 2.30
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Khsrp) mRNA processing (Khsrp) RNA binding (Khsrp)
nucleus (Khsrp) DNA binding (Khsrp) cytoplasm (Khsrp)
Khsrp (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 134 99.24 Very High Very High Very High
Inflammation 465 98.84 Very High Very High Very High
Arthritis 21 88.88 High High
Kinase C 17 75.04 Quite High
Inflammatory stimuli 12 70.08 Quite High
Inflammatory response 16 67.04 Quite High
chemokine 40 61.72 Quite High
cINOD 21 30.32 Quite Low
aspirin 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 482 98.84 Very High Very High Very High
Cancer 577 92.72 High High
Targeted Disruption 34 91.76 High High
Experimental Arthritis 4 89.60 High High
Disease 39 86.64 High High
Arthritis 17 61.44 Quite High
Congenital Anomalies 11 57.28 Quite High
Stress 15 43.08 Quite Low
Colon Cancer 32 26.28 Quite Low
Apoptosis 17 6.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
can phosphorylate KSRP leading to loss of its binding activity to ARE and subsequently mRNA stabilization [93, 124].
Phosphorylation (phosphorylate) of KSRP
1) Confidence 0.52 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.37 Pain Relevance 0.14
In addition, KHSRP is phosphorylated by p38 MAPK and its phosphorylation is accompanied by reduced binding to target mRNAs and increased target mRNA stability (Linker et al., 2005; Chou et al., 2006).
Phosphorylation (phosphorylated) of KHSRP
2) Confidence 0.49 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639449 Disease Relevance 0.13 Pain Relevance 0.03
-catenin pathway by inactivating the RNA decay properties of KSRP through AKT-mediated phosphorylation at a unique serine residue in KSRP, that results in association with the multifunctional protein 14-3-3 and prevents KSRP interaction with the exoribonucleolytic complex exosome [94].
Phosphorylation (phosphorylation) of KSRP
3) Confidence 0.44 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.62 Pain Relevance 0.28
Activation of the p38 MAPK pathway leads to MK2-mediated phosphorylation of TTP and KSRP leading to loss of function of these RNA-binding proteins, e.g., reduced affinity to ARE regions, and subsequently ARE-mRNA stabilization (Fig. 2) [122–124].
Phosphorylation (phosphorylation) of KSRP
4) Confidence 0.40 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.23 Pain Relevance 0.21
One of those is the p38 MAPK pathway that leads to phosphorylation and inactivation of the activity of the RNA decay-promoting proteins such as TTP and KSRP.
Phosphorylation (phosphorylation) of KSRP
5) Confidence 0.15 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.95 Pain Relevance 0.33

General Comments

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