INT260906

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.48
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Khsrp) mRNA processing (Khsrp) RNA binding (Khsrp)
nucleus (Khsrp) DNA binding (Khsrp) cytoplasm (Khsrp)
Khsrp (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 134 99.76 Very High Very High Very High
Inflammation 465 99.56 Very High Very High Very High
Inflammatory stimuli 12 93.68 High High
Arthritis 21 79.36 Quite High
chemokine 40 5.00 Very Low Very Low Very Low
cINOD 21 5.00 Very Low Very Low Very Low
Kinase C 17 5.00 Very Low Very Low Very Low
Inflammatory response 16 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 482 99.56 Very High Very High Very High
Cancer 577 90.60 High High
Targeted Disruption 34 87.64 High High
Arthritis 17 79.36 Quite High
Stress 15 61.00 Quite High
Bacterial Infection 4 40.00 Quite Low
Shock 4 23.04 Low Low
Intellectual Impairment 4 14.00 Low Low
Disease 39 11.48 Low Low
Hypoxia 45 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pro-inflammatory cytokines can reduce KSRP binding and enhance HuR binding to iNOS 3?
KSRP Binding (binding) of associated with inflammation and cytokine
1) Confidence 0.30 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.54 Pain Relevance 0.21
KHSRP also regulates mRNA turnover by binding to AREs, and interactions with the exosome and deadenylases (Linker et al., 2005; Chou et al., 2006).
KHSRP Binding (binding) of
2) Confidence 0.28 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639449 Disease Relevance 0.23 Pain Relevance 0.04
Associations of KSRP and AUF1 p45, or KSRP and HuR, allow fine tuning of ARE-mRNA stability [93, 94].
KSRP Binding (Associations) of
3) Confidence 0.23 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.36 Pain Relevance 0.14
Tristetraprolin and several other RNA-binding proteins such as BRF1, KSRP, and AUF1 appear to function by targeting AU-rich mRNA to the exosome, a multiprotein complex with 3?
KSRP Binding (binding) of
4) Confidence 0.23 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.05 Pain Relevance 0.04
Associations of KSRP and AUF1 p45, or KSRP and HuR, allow fine tuning of ARE-mRNA stability [93, 94].
KSRP Binding (Associations) of
5) Confidence 0.23 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.30 Pain Relevance 0.14

General Comments

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