INT260916

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Context Info
Confidence 0.21
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.47
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Elavl1) nucleus (Elavl1) cytoplasm (Elavl1)
Anatomy Link Frequency
finger 1
Elavl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 13 99.16 Very High Very High Very High
Inflammation 349 93.04 High High
cytokine 101 67.36 Quite High
chemokine 30 5.00 Very Low Very Low Very Low
cINOD 16 5.00 Very Low Very Low Very Low
Arthritis 16 5.00 Very Low Very Low Very Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
Inflammatory stimuli 9 5.00 Very Low Very Low Very Low
aspirin 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 15 95.84 Very High Very High Very High
Cancer 433 93.48 High High
INFLAMMATION 362 93.04 High High
Targeted Disruption 28 88.56 High High
Male Infertility 2 85.44 High High
Congenital Anomalies 9 68.48 Quite High
Disease 30 63.72 Quite High
Inflammatory Bowel Disease 12 55.52 Quite High
Colon Cancer 24 53.84 Quite High
Colitis 18 52.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the latter case, the different alternative variants have differential response to HuR-induced stabilization and destabilization to TTP and other mRNA decay players [73, 146].
Regulation (response) of HuR
1) Confidence 0.21 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.48 Pain Relevance 0.07
HuR phosphorylation by p38 MAPK, cAMP kinase, PKC, and cell-cycle G2-phase kinase Cdk1 can regulate HuR shuttling and thus affect the mRNA stabilization outcome [128, 160, 161].
Regulation (regulate) of HuR associated with kinase c
2) Confidence 0.12 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.06 Pain Relevance 0.20
A polyadenylation ARE-mRNA transcript variant of HuR has recently been uncovered and is responsive to HuR auto-regulation and to wild-type TTP mRNA decay action but not to the zinc-finger mutant (C124R)[73].
Regulation (regulation) of HuR in finger
3) Confidence 0.12 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.60 Pain Relevance 0.12
These results are important because studies have determined that ELAVL1, ZFP36 and KHSRP RBPs are downstream targets of p38 MAPK ?
Regulation (targets) of ELAVL1
4) Confidence 0.08 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639449 Disease Relevance 0.33 Pain Relevance 0

General Comments

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