INT260916

Context Info Confidence 0.21 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 4 Disease Relevance 2.47 Pain Relevance 0.38

RNA binding (Elavl1) nucleus (Elavl1) cytoplasm (Elavl1)

Anatomy Link Frequency finger 1 Elavl1 (Mus musculus)

Pain Link Frequency Relevance Heat Kinase C 13 99.16 Inflammation 349 93.04 cytokine 101 67.36 chemokine 30 5.00 cINOD 16 5.00 Arthritis 16 5.00 Inflammatory response 12 5.00 Inflammatory stimuli 9 5.00 aspirin 3 5.00 Inflammatory mediators 3 5.00

Disease Link Frequency Relevance Heat Breast Cancer 15 95.84 Cancer 433 93.48 INFLAMMATION 362 93.04 Targeted Disruption 28 88.56 Male Infertility 2 85.44 Congenital Anomalies 9 68.48 Disease 30 63.72 Inflammatory Bowel Disease 12 55.52 Colon Cancer 24 53.84 Colitis 18 52.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the latter case, the different alternative variants have differential response to HuR-induced stabilization and destabilization to TTP and other mRNA decay players [73, 146].

Regulation (response) of HuR

1) Confidence 0.21 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.48 Pain Relevance 0.07

HuR phosphorylation by p38 MAPK, cAMP kinase, PKC, and cell-cycle G2-phase kinase Cdk1 can regulate HuR shuttling and thus affect the mRNA stabilization outcome [128, 160, 161].

Regulation (regulate) of HuR associated with kinase c

2) Confidence 0.12 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.06 Pain Relevance 0.20

A polyadenylation ARE-mRNA transcript variant of HuR has recently been uncovered and is responsive to HuR auto-regulation and to wild-type TTP mRNA decay action but not to the zinc-finger mutant (C124R)[73].

Regulation (regulation) of HuR in finger

3) Confidence 0.12 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.60 Pain Relevance 0.12

These results are important because studies have determined that ELAVL1, ZFP36 and KHSRP RBPs are downstream targets of p38 MAPK ?

Regulation (targets) of ELAVL1

4) Confidence 0.08 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639449 Disease Relevance 0.33 Pain Relevance 0

General Comments

This test has worked.