INT260917

Context Info Confidence 0.32 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 5 Disease Relevance 4.10 Pain Relevance 0.41

RNA binding (Elavl1) nucleus (Elavl1) cytoplasm (Elavl1)

Anatomy Link Frequency MDA-MB-231 2 Elavl1 (Mus musculus)

Pain Link Frequency Relevance Heat Kinase C 17 99.12 Inflammation 465 61.96 Arthritis 21 60.32 cytokine 134 54.80 chemokine 40 5.00 cINOD 21 5.00 Inflammatory response 16 5.00 Inflammatory stimuli 12 5.00 aspirin 4 5.00 Inflammatory mediators 4 5.00

Disease Link Frequency Relevance Heat Cancer 577 99.90 Breast Cancer 20 98.88 Stress 15 98.40 Ovarian Cancer 8 94.56 Colon Cancer 32 84.96 Glioblastoma 4 73.92 Lung Cancer 8 71.20 INFLAMMATION 482 61.96 Arthritis 17 60.32 Hyperplasia 20 59.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The overexpression of constitutively active MK2 results in increased HuR cytoplasmic localization in the MDA-MB-231 invasive breast cancer line [129].

Positive_regulation (increased) of Localization (localization) of HuR in MDA-MB-231 associated with breast cancer

1) Confidence 0.32 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.01 Pain Relevance 0.18

Increased cytoplasmic localization of ELAVL1 protein is associated with increased oxidative stress and enhanced MAPKAPK2/3 phosphorylation (Lal et al., 2004; Raineri et al., 2004; Cherry et al., 2006).

Positive_regulation (Increased) of Localization (localization) of ELAVL1 protein associated with stress

2) Confidence 0.32 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639449 Disease Relevance 0.16 Pain Relevance 0.03

Certain signaling aberrations in cancer may promote cytoplasmic HuR localization such as p38 MAPK and PKC pathways.

Positive_regulation (promote) of Localization (localization) of HuR associated with kinase c and cancer

3) Confidence 0.28 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.96 Pain Relevance 0.09

Several studies have pointed out that HuR is overexpressed in tumor cells when compared to their normal counterparts, with increased localization of HuR in cytoplasmic compartments.

Positive_regulation (increased) of Localization (localization) of HuR associated with cancer

4) Confidence 0.23 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.90 Pain Relevance 0.03

How is cytoplasmic localization of HuR promoted in tumor cells?

Positive_regulation (promoted) of Localization (localization) of HuR associated with cancer

5) Confidence 0.21 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.07 Pain Relevance 0.08

General Comments

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