INT260918

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Context Info
Confidence 0.28
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.33
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Khsrp) mRNA processing (Khsrp) RNA binding (Khsrp)
nucleus (Khsrp) DNA binding (Khsrp) cytoplasm (Khsrp)
Khsrp (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 233 96.60 Very High Very High Very High
cytokine 68 95.66 Very High Very High Very High
Kinase C 9 72.48 Quite High
Inflammatory stimuli 6 34.56 Quite Low
chemokine 20 5.00 Very Low Very Low Very Low
cINOD 11 5.00 Very Low Very Low Very Low
Arthritis 11 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 289 96.82 Very High Very High Very High
INFLAMMATION 242 96.60 Very High Very High Very High
Male Infertility 2 84.72 Quite High
Breast Cancer 10 70.00 Quite High
Congenital Anomalies 7 67.76 Quite High
Targeted Disruption 22 63.04 Quite High
Reprotox - General 3 2 45.76 Quite Low
Glioma 4 28.32 Quite Low
Disease 21 23.28 Low Low
Hypoxia 23 20.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tristetraprolin and several other RNA-binding proteins such as BRF1, KSRP, and AUF1 appear to function by targeting AU-rich mRNA to the exosome, a multiprotein complex with 3?
Regulation (function) of KSRP
1) Confidence 0.28 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.05 Pain Relevance 0.04
These results are important because studies have determined that ELAVL1, ZFP36 and KHSRP RBPs are downstream targets of p38 MAPK ?
Regulation (targets) of KHSRP
2) Confidence 0.21 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639449 Disease Relevance 0.33 Pain Relevance 0
Continued secretion of cytokines and growth factors during chronic inflammation and cancer contribute to a prolonged state of activated pathways such as the MAPK pathway that maintains mRNA stabilization by inactivation of RNA-binding proteins that participate in mRNA decay such as TTP and KSRP (Fig. 2).
Regulation (participate) of KSRP associated with inflammation, cancer and cytokine
3) Confidence 0.17 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.95 Pain Relevance 0.21

General Comments

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