INT260961

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 5.46
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
molar 4
blood 2
vesicles 1
Gd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
imagery 463 99.60 Very High Very High Very High
agonist 74 95.44 Very High Very High Very High
isoflurane 21 93.36 High High
b2 receptor 59 92.56 High High
bradykinin 72 84.04 Quite High
anesthesia 21 35.60 Quite Low
Thalamus 12 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioma 881 100.00 Very High Very High Very High
Cancer 781 99.40 Very High Very High Very High
Renal Disease 2 76.32 Quite High
Toxicity 22 51.60 Quite High
Brain Tumor 308 50.00 Quite Low
Malignant Neoplastic Disease 84 50.00 Quite Low
Solid Tumor 53 5.00 Very Low Very Low Very Low
Nephrogenic Fibrosing Dermopathy 6 5.00 Very Low Very Low Very Low
Breast Cancer 4 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro magnetic resonance imaging for calculations of Gd-dendrimer molar relaxivity
Localization (relaxivity) of Gd-dendrimer in molar associated with imagery
1) Confidence 0.45 Published 2009 Journal J Transl Med Section Body Doc Link PMC2706803 Disease Relevance 0 Pain Relevance 0.15
The Gd-dendrimer was infused as a slow bolus, over 1 minute, so that the blood pharmacokinetics of the respective Gd-dendrimer generation could be accurately measured during the early time points.
Localization (generation) of Gd-dendrimer in blood
2) Confidence 0.45 Published 2009 Journal J Transl Med Section Body Doc Link PMC2706803 Disease Relevance 0.07 Pain Relevance 0.07
The physical properties of the rhodamine B dendrimers were similar to those of the Gd-G2, Gd-G5, and Gd-G8 dendrimers.
Localization (those) of Gd-G2
3) Confidence 0.32 Published 2008 Journal J Transl Med Section Body Doc Link PMC2639552 Disease Relevance 0.57 Pain Relevance 0
The physical properties of the rhodamine B dendrimers were similar to those of the Gd-G2, Gd-G5, and Gd-G8 dendrimers.
Localization (those) of Gd-G5
4) Confidence 0.32 Published 2008 Journal J Transl Med Section Body Doc Link PMC2639552 Disease Relevance 0.57 Pain Relevance 0
The subcellular localization of rhodamine Gd-G5 dendrimers in tumor tissue was minimal to what was observed in cultured glioma cells (Figure 5E, top right).
Localization (localization) of Gd-G5 associated with cancer and glioma
5) Confidence 0.29 Published 2008 Journal J Transl Med Section Body Doc Link PMC2639552 Disease Relevance 0.86 Pain Relevance 0.10
The subcellular localization of rhodamine B Gd-G5 dendrimers in tumor tissue was similar to what was observed in cultured RG-2 glioma cells (high power, Figure 5D, top right).
Localization (localization) of Gd-G5 associated with cancer and glioma
6) Confidence 0.29 Published 2008 Journal J Transl Med Section Body Doc Link PMC2639552 Disease Relevance 0.85 Pain Relevance 0.10
Rhodamine B Gd-G8 dendrimers localize within glioma cells as readily as rhodamine B Gd-G5 dendrimers indicating that cellular uptake was not the barrier to the accumulation of higher generation Gd-dendrimers within glioma cells.
Localization (localize) of Gd-G5 associated with glioma
7) Confidence 0.28 Published 2008 Journal J Transl Med Section Body Doc Link PMC2639552 Disease Relevance 0.69 Pain Relevance 0.04
In addition, rhodamine B Gd-G2 dendrimers in some cases were observed to localize within cell nuclei (Figure 5B, left).
Localization (localize) of Gd-G2
8) Confidence 0.28 Published 2008 Journal J Transl Med Section Body Doc Link PMC2639552 Disease Relevance 0.67 Pain Relevance 0.04
Rhodamine B Gd-G2, rhodamine B Gd-G5 or rhodamine B Gd-G8 dendrimers were added to the medium by equivalent molar rhodamine B concentrations of 7.2 ?
Localization (rhodamine) of Gd-G5 in molar
9) Confidence 0.28 Published 2008 Journal J Transl Med Section Body Doc Link PMC2639552 Disease Relevance 0.18 Pain Relevance 0.03
Rhodamine B Gd-G2, rhodamine B Gd-G5 or rhodamine B Gd-G8 dendrimers were added to the medium by equivalent molar rhodamine B concentrations of 7.2 ?
Localization (rhodamine) of Gd-G2 in molar
10) Confidence 0.28 Published 2008 Journal J Transl Med Section Body Doc Link PMC2639552 Disease Relevance 0.18 Pain Relevance 0.03
Fluorescence microscopy of RG-2 glioma specimens demonstrated extensive subcellular localization of rhodamine B Gd-G5 dendrimers, confirming that functionalized G5 dendrimers accumulate within malignant glioma cells, due to long blood half-lives.
Localization (localization) of Gd-G5 in blood associated with glioma
11) Confidence 0.26 Published 2008 Journal J Transl Med Section Body Doc Link PMC2639552 Disease Relevance 0.62 Pain Relevance 0.09
In vitro magnetic resonance imaging for calculation of Gd-DTPA molar relaxivity
Localization (relaxivity) of Gd-DTPA in molar associated with imagery
12) Confidence 0.15 Published 2009 Journal J Transl Med Section Body Doc Link PMC2689161 Disease Relevance 0.12 Pain Relevance 0.58
While others have explored DTPA-PE in lipid vesicles or liposomes to enhance relaxivity of Gd-DTPA, reported r1 values were around 10–12 mM?
Localization (relaxivity) of Gd-DTPA in vesicles
13) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948015 Disease Relevance 0.08 Pain Relevance 0.03

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