INT260964

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Context Info
Confidence 0.07
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.08
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Rg9mtd2)
Anatomy Link Frequency
anterior 2
brain 1
Rg9mtd2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 296 99.04 Very High Very High Very High
imagery 136 98.88 Very High Very High Very High
bradykinin 288 98.74 Very High Very High Very High
b2 receptor 236 98.68 Very High Very High Very High
anesthesia 11 67.92 Quite High
isoflurane 9 64.08 Quite High
Thalamus 14 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioma 528 100.00 Very High Very High Very High
Cancer 609 99.68 Very High Very High Very High
Brain Tumor 248 97.92 Very High Very High Very High
Solid Tumor 37 58.32 Quite High
Malignant Neoplastic Disease 56 50.00 Quite Low
Increased Venous Pressure Under Development 8 5.00 Very Low Very Low Very Low
Toxicity 5 5.00 Very Low Very Low Very Low
Pressure Volume 2 Under Development 4 5.00 Very Low Very Low Very Low
Breast Cancer 2 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the Met-Lys-BK group to NS group comparison, there was a significant percent increase in Gd-DTPA AUC for anterior brain (p = 0.0008) but not posterior brain (p = 0.0600) RG-2 gliomas (Figure 7A and 7B).
Positive_regulation (increase) of RG-2 in anterior associated with bradykinin and glioma
1) Confidence 0.07 Published 2009 Journal J Transl Med Section Body Doc Link PMC2689161 Disease Relevance 0.92 Pain Relevance 0.46
We found that with an increase in RG-2 glioma tumor volume, there was also an increase in tumor tissue Ktrans (F1,66.4 = 47.60, p < 0.0001), ve (F1,75 = 47.14, p < 0.0001), and vp (F1,54.7 = 10.79, p = 0.0018) (Figure 1A through 1C).
Positive_regulation (increase) of RG-2 associated with cancer and glioma
2) Confidence 0.07 Published 2009 Journal J Transl Med Section Body Doc Link PMC2689161 Disease Relevance 1.22 Pain Relevance 0.18
Orthotopic and ectopic RG-2 glioma induction and animal preparation for imaging
Positive_regulation (induction) of RG-2 associated with imagery and glioma
3) Confidence 0.06 Published 2009 Journal J Transl Med Section Body Doc Link PMC2706803 Disease Relevance 0.19 Pain Relevance 0.15
The statistically significant increase in Ktrans of the BBTB of anterior RG-2 gliomas that we observed with intravenous Met-Lys-BK infusion would be attributable to the combination of: (1) a higher affinity than labradimil for the bradykinin B2 receptors over-expressed on tumor microvasculature and thereby, greater ability to vasodilate tumor microvasculature and increase the permeability of the BBTB; and (2) the lesser metabolic stability than labradimil resulting in a less significant fall in MABP than that caused by labradimil infusion.
Positive_regulation (increase) of RG-2 in anterior associated with cancer, bradykinin and glioma
4) Confidence 0.05 Published 2009 Journal J Transl Med Section Body Doc Link PMC2689161 Disease Relevance 0.96 Pain Relevance 0.52
Likewise, in the labradimil group to NS group comparison, there was a significant percent increase in Gd-DTPA AUC for anterior brain (p = 0.0235) but not posterior brain (p = 0.1286) RG-2 gliomas (Figure 7A and 7B).
Positive_regulation (increase) of RG-2 in brain associated with glioma
5) Confidence 0.04 Published 2009 Journal J Transl Med Section Body Doc Link PMC2689161 Disease Relevance 0.76 Pain Relevance 0.56
We found that rhodamine B labeled Gd-G2, -G5 and -G8 dendrimers accumulated in the cytoplasm of all RG-2 glioma cells; however, we found it particularly interesting that, in some cases, rhodamine B labeled Gd-G2 dendrimers also accumulated in the RG-2 glioma cell nuclei.
Positive_regulation (accumulated) of RG-2 associated with glioma
6) Confidence 0.04 Published 2008 Journal J Transl Med Section Body Doc Link PMC2639552 Disease Relevance 0.49 Pain Relevance 0.09
At the 0.09 mmol Gd/kg bw dose, irrespective of tumor size, Gd-G5 and Gd-G6 dendrimers continued to accumulate slowly over 2 hours in all RG-2 gliomas (Figure 2 and Figure 3).
Positive_regulation (accumulate) of RG-2 associated with cancer and glioma
7) Confidence 0.04 Published 2008 Journal J Transl Med Section Body Doc Link PMC2639552 Disease Relevance 0.55 Pain Relevance 0

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