INT261021

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Context Info
Confidence 0.67
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.45
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Gclm (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory response 7 71.68 Quite High
Inflammation 75 58.24 Quite High
cytokine 18 5.00 Very Low Very Low Very Low
Glutamate 17 5.00 Very Low Very Low Very Low
ischemia 12 5.00 Very Low Very Low Very Low
Inflammatory marker 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 240 98.88 Very High Very High Very High
Neurodegenerative Disease 10 88.32 High High
INFLAMMATION 87 71.68 Quite High
Sprains And Strains 24 63.76 Quite High
Stress 58 54.24 Quite High
Colitis 3 53.88 Quite High
Disease 18 46.40 Quite Low
Apoptosis 94 23.36 Low Low
Critical Illness 18 5.00 Very Low Very Low Very Low
Systemic Inflammatory Response Syndrome 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, we speculate that increased microglial expression of Srxn1, Blvrb, and Gclm is also mediated by activation of Nrf2.
Positive_regulation (increased) of Gene_expression (expression) of Gclm
1) Confidence 0.67 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819254 Disease Relevance 0.22 Pain Relevance 0.06
Therefore, we speculate that increased microglial expression of Srxn1, Blvrb, and Gclm is also mediated by activation of Nrf2.
Positive_regulation (increased) of Gene_expression (expression) of Gclm
2) Confidence 0.49 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819254 Disease Relevance 0.22 Pain Relevance 0.06
The increase in GCLm mRNA expression was less pronounced in the AP and placebo groups when compared to sham operated animals (3.07 vs.
Positive_regulation (increase) of Gene_expression (expression) of GCLm mRNA associated with pancreatitis
3) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639703 Disease Relevance 0.44 Pain Relevance 0
On the other hand, we found enhanced GCL activity and expression of the GCL subunits GCLc and GCLm in probiotic-treated animals leading to a significant increase in GSH contents.
Positive_regulation (activity) of Gene_expression (expression) of GCLm
4) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639703 Disease Relevance 0.23 Pain Relevance 0
Because GCL is composed of both a catalytic and modulatory subunit [37], the increase in GCL activity in this study could be due to enhanced expression of either GCLm and/or GCLc.
Positive_regulation (enhanced) of Gene_expression (expression) of GCLm
5) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639703 Disease Relevance 0.35 Pain Relevance 0

General Comments

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