INT261048

Context Info Confidence 0.03 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.21 Pain Relevance 0.21

cytosol (CA2) extracellular space (CA2) lyase activity (CA2) response to stress (CA2) cytoplasm (CA2)

CHR (Homo sapiens) CA2 (Homo sapiens)

Pain Link Frequency Relevance Heat Calcium channel 34 99.52 antagonist 2 85.76 Inflammatory stimuli 4 76.16 imagery 8 49.36 Inflammation 20 10.04 Catecholamine 12 5.00 medulla 8 5.00 cytokine 2 5.00 Inflammatory response 2 5.00 Pain 2 5.00

Disease Link Frequency Relevance Heat Fungal Infection 2 83.76 INFLAMMATION 26 75.84 Shock 4 53.68 Apoptosis 4 5.00 Infection 4 5.00 Pain 2 5.00 Death 2 5.00 Disease 2 5.00 Stress 2 5.00

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Hence, these findings indicate that CAT and CHR, being unable to evoke a Ca2+ mobilization from intracellular stores in absence of extracellular Ca2+, by their 2-APB sensitive induction of Ca2+ entry via SOCs may converge on iPLA2 in a manner similar to the two CaM inhibitors W7 and CMZ.

CHR Positive_regulation (induction) of Ca2 associated with calcium channel

1) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639705 Disease Relevance 0.05 Pain Relevance 0.18

In PMNs loaded with Fluo-3, a transient Ca2+ influx was induced by 20 µM of either CHR or CAT (20 µM) in the presence, but not in the absence, of 1 mM free extracellular Ca2+ (Figure 1A).

CHR Positive_regulation (induced) of Ca2

2) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639705 Disease Relevance 0.16 Pain Relevance 0.04

General Comments

This test has worked.