INT261058

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Context Info
Confidence 0.04
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.14
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CALM3) small molecule metabolic process (CALM3) carbohydrate metabolic process (CALM3)
cytoplasm (CALM3) cytosol (CALM3) signal transduction (CALM3)
CALM3 (Homo sapiens)
CHR (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcium channel 85 88.00 High High
antagonist 5 49.36 Quite Low
Inflammatory response 5 15.44 Low Low
Inflammation 50 5.00 Very Low Very Low Very Low
Catecholamine 30 5.00 Very Low Very Low Very Low
imagery 20 5.00 Very Low Very Low Very Low
medulla 20 5.00 Very Low Very Low Very Low
Inflammatory stimuli 10 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 5 81.92 Quite High
Infection 10 54.76 Quite High
INFLAMMATION 65 15.04 Low Low
Apoptosis 10 5.00 Very Low Very Low Very Low
Shock 10 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Fungal Infection 5 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low
Stress 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, CaM interacts with both CHR and CAT (Figure 5C2) when assayed by CaM-binding affinity chromatography and dot blot immunodetection of CgA in the fixed material with anti-CHR (monoclonal anti-CGA47–66) [14] and anti-CAT (polyclonal anti-CGA344–364) [17].


CaM Binding (interacts) of CHR
1) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639705 Disease Relevance 0 Pain Relevance 0.09
Interactions between CaM, CAT and CHR were assessed by surface plasmon resonance (SPR) (Figure 5 C1), revealing that not only CHR but also CAT specifically interacted with CaM, while scrambled CAT was inactive.
CaM Binding (interacted) of CHR
2) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639705 Disease Relevance 0 Pain Relevance 0.09
Interestingly, a comparison of CHR and CAT sequences with two CaM-binding peptides of iPLA2 reveals marked homologies (Figure 6D).
CaM Binding (comparison) of CHR
3) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639705 Disease Relevance 0 Pain Relevance 0.11
The present experiments have demonstrated that the two CgA peptides, CHR and CAT, penetrate rapidly into PMNs (Figure 5A) and subsequently interact with CaM (Figure 5C) to activate iPLA2 (Figure 6C).
CaM Binding (interact) of CHR
4) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639705 Disease Relevance 0.14 Pain Relevance 0.04
The two cationic sequences CAT and CHR may be aligned with two Ca2+- dependent CaM binding motifs 1-8-14 B and 1-5-10 [39], as illustrated in Figure 5 B and previously demonstrated for binding of CHR to CaM [24], [40].
CaM Binding (binding) of CHR
5) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639705 Disease Relevance 0 Pain Relevance 0.03

General Comments

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