INT261081

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Context Info
Confidence 0.15
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.41
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (LTA4H) peptidase activity (LTA4H) small molecule metabolic process (LTA4H)
nucleolus (LTA4H) nucleus (LTA4H) cytoplasm (LTA4H)
Anatomy Link Frequency
Platelets 1
neutrophils 1
LTA4H (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 59 81.32 Quite High
cytokine 2 79.92 Quite High
metalloproteinase 1 60.00 Quite High
aspirin 8 50.64 Quite High
substance P 1 48.16 Quite Low
Catecholamine 6 40.56 Quite Low
Potency 1 37.04 Quite Low
alcohol 1 33.44 Quite Low
agonist 4 13.92 Low Low
Calcium channel 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 1 96.76 Very High Very High Very High
Apoptosis 4 92.76 High High
INFLAMMATION 72 81.32 Quite High
Disease 6 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low
Shock 2 5.00 Very Low Very Low Very Low
Infection 2 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Adhesions 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Leukotriene A-4 hydrolase is released by the specific granules of neutrophils.
Localization (released) of A-4 hydrolase in neutrophils
1) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639705 Disease Relevance 0.35 Pain Relevance 0.15
Platelets adhering to neutrophils can pick up and transform released 5-LO intermediate LTA4 and convert this to LXA4 and LXB4 by platelet 12-LO.[56]

Membrane phospholipid priming, stored precursors of 15-HETE

Localization (released) of LTA4 in Platelets
2) Confidence 0.02 Published 2010 Journal Journal of Indian Society of Periodontology Section Body Doc Link PMC2933521 Disease Relevance 0.06 Pain Relevance 0.06

General Comments

This test has worked.

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