INT2611

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Context Info
Confidence 0.39
First Reported 1979
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 10.04
Pain Relevance 2.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transporter activity (AQP1) plasma membrane (AQP1) nucleus (AQP1)
transmembrane transport (AQP1) cytoplasm (AQP1)
Anatomy Link Frequency
Urine 4
eye 1
glial cells 1
suture 1
AQP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
potassium channel 8 99.96 Very High Very High Very High
Deafferentation 24 99.82 Very High Very High Very High
Pain 9 99.82 Very High Very High Very High
cINOD 3 99.74 Very High Very High Very High
cva 5 99.40 Very High Very High Very High
Central nervous system 146 99.32 Very High Very High Very High
tetrodotoxin 31 99.16 Very High Very High Very High
Facet joint 1 97.12 Very High Very High Very High
Action potential 12 96.20 Very High Very High Very High
cerebral cortex 4 95.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Optic Nerve Injuries 210 99.92 Very High Very High Very High
Pain 8 99.82 Very High Very High Very High
Ocular Hypertension 426 99.80 Very High Very High Very High
INFLAMMATION 42 99.62 Very High Very High Very High
Cv General 3 Under Development 5 99.40 Very High Very High Very High
Creutzfeldt Jakob Disease 20 99.08 Very High Very High Very High
Lewy Body Disease 6 98.56 Very High Very High Very High
Disease 168 98.08 Very High Very High Very High
Sclerosis 1 97.52 Very High Very High Very High
Frailty 30 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unfortunately, there are only few other agents that inhibits AQPs: silver salts inhibit AQP1 [70]; tetraethyl ammonium, which is widely used as a blocker of potassium channels, blocks AQP1 [16]; and phloretin is a relatively potent inhibitor of several AQPs, including AQP9 [92].
Negative_regulation (inhibit) of AQP1 associated with potassium channel
1) Confidence 0.39 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923373 Disease Relevance 0.09 Pain Relevance 0.08
in a transient expression system of HEK293 cells in vitro, reporting AQP1 and A?
Negative_regulation (reporting) of AQP1
2) Confidence 0.25 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 0.79 Pain Relevance 0.08
Significant increased expression levels of AQP1 and AQP4 were seen in CJD, but not in advanced AD and DLB cases.
Negative_regulation (levels) of AQP1 associated with creutzfeldt jakob disease, lewy body disease and disease
3) Confidence 0.25 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.49 Pain Relevance 0.05
Unfortunately, there are only few other agents that inhibits AQPs: silver salts inhibit AQP1 [70]; tetraethyl ammonium, which is widely used as a blocker of potassium channels, blocks AQP1 [16]; and phloretin is a relatively potent inhibitor of several AQPs, including AQP9 [92].
Negative_regulation (blocks) of AQP1 associated with potassium channel
4) Confidence 0.25 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923373 Disease Relevance 0.09 Pain Relevance 0.08
From 1 day to 7 days after monocular impulse blockade with tetrodotoxin, there was a progressive reduction of NRF-2 alpha in deprived ocular dominance columns, in parallel with decreases in CO activity.
Negative_regulation (decreases) of CO associated with tetrodotoxin
5) Confidence 0.19 Published 1999 Journal J. Comp. Neurol. Section Abstract Doc Link 9952350 Disease Relevance 0 Pain Relevance 0.10
It is thought that the nonsteroidal anti-inflammatory drugs act through inhibition of cyclooxygenase (CO).
Negative_regulation (inhibition) of CO associated with inflammation and cinod
6) Confidence 0.08 Published 1979 Journal Schweiz Med Wochenschr Section Abstract Doc Link 482916 Disease Relevance 0.26 Pain Relevance 0.18
These effects are independent of the prostaglandin-thromboxane system, since other CO inhibitors are uneffective.
Negative_regulation (inhibitors) of CO
7) Confidence 0.06 Published 1979 Journal Schweiz Med Wochenschr Section Abstract Doc Link 482916 Disease Relevance 0.38 Pain Relevance 0.08
Cooper and Muir [12] have shown only a moderate decline of PulseCO after induced haemorrhage in healthy dogs, with significant bias between PulseCO and lithium indicator dilution CO.
Negative_regulation (decline) of PulseCO associated with cva
8) Confidence 0.03 Published 2008 Journal Crit Care Section Body Doc Link PMC2592771 Disease Relevance 0.42 Pain Relevance 0.05
Urine antiproliferative factor activity decreased significantly after hydrodistention in patients with interstitial cystitis.
Negative_regulation (decreased) of Urine antiproliferative factor in Urine
9) Confidence 0.02 Published 2000 Journal J. Urol. Section Body Doc Link 10751853 Disease Relevance 0.07 Pain Relevance 0
Studies have revealed that the activity of the mitochondrial enzyme, cytochrome oxidase (CO) is reduced after monocular visual deprivation by lid suture (MD), tetrodotoxin (TTX) injection, enucleation, and optic nerve transection (ONT) in adult cats and primates [1-8].
Negative_regulation (deprivation) of CO in suture associated with tetrodotoxin and optic nerve injuries
10) Confidence 0.02 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773743 Disease Relevance 1.14 Pain Relevance 0.24
Urine NTx and BSAP remained suppressed with continuous alendronate, but increased by about 25% when treatment was discontinued although they remained below baseline for the 5 years of observation
Negative_regulation (suppressed) of Urine NTx in Urine
11) Confidence 0.01 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936260 Disease Relevance 0.10 Pain Relevance 0.05
Vision loss by unilateral OHT caused a downregulation of CO activity in the LGN layers innervated by the OHT eye in all six brains processed.
Negative_regulation (downregulation) of CO in eye associated with ocular hypertension
12) Confidence 0.01 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773743 Disease Relevance 0.79 Pain Relevance 0
Loss of CO activity in the CNS after monocular vision loss in the adult primate has been documented as early as 14 h after an intraocular TTX injection, and thus represents one of the earliest measurable responses to loss of visual inputs to the retinogeniculocortical pathway [57].
Negative_regulation (Loss) of CO associated with tetrodotoxin and central nervous system
13) Confidence 0.01 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773743 Disease Relevance 1.21 Pain Relevance 0.29
The example shown in Figure 3A is from an animal in whom the ipsilateral hemisphere was processed, and thus the downregulation in CO activity was evident in layers 2 (magnocellular) and layers 3, 5 (parvocellular) of the LGN (Figure 3D,E).
Negative_regulation (downregulation) of CO
14) Confidence 0.01 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773743 Disease Relevance 0.66 Pain Relevance 0
The example shown in Figure 5A is from an animal in whom the contralateral hemisphere was processed, and thus the downregulation in CO activity was evident in layers 1, 4, and 6.
Negative_regulation (downregulation) of CO
15) Confidence 0.01 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773743 Disease Relevance 0.83 Pain Relevance 0
Among the earliest cellular events after sensory deafferentation are the loss of CO activity and the activation of glial cells, which have been shown to occur within hours after action potential blockage by TTX injection or deafferentation [3,30-32].
Negative_regulation (loss) of CO in glial cells associated with tetrodotoxin, action potential and deafferentation
16) Confidence 0.01 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773743 Disease Relevance 1.11 Pain Relevance 0.51
Bone healing was usually accompanied by pain relief, reduction in skin temperature and rapid suppression of the urine hydroxyproline (uHP) into the normal range.
Negative_regulation (reduction) of urine hydroxyproline in urine associated with pain
17) Confidence 0.00 Published 1987 Journal Br J Radiol Section Abstract Doc Link 3117159 Disease Relevance 0.31 Pain Relevance 0.18
Bone healing was usually accompanied by pain relief, reduction in skin temperature and rapid suppression of the urine hydroxyproline (uHP) into the normal range.
Negative_regulation (suppression) of urine hydroxyproline in urine associated with pain
18) Confidence 0.00 Published 1987 Journal Br J Radiol Section Abstract Doc Link 3117159 Disease Relevance 0.31 Pain Relevance 0.18

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