INT261118

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Context Info
Confidence 0.07
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 4.03
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnfrsf10b)
Anatomy Link Frequency
skin 1
Tnfrsf10b (Mus musculus)
Pain Link Frequency Relevance Heat
pruritus 5 72.68 Quite High
cytokine 3 63.40 Quite High
Inflammation 1 20.40 Low Low
imagery 8 5.00 Very Low Very Low Very Low
psoriasis 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 20 100.00 Very High Very High Very High
Cancer 103 99.48 Very High Very High Very High
Syndrome 31 99.44 Very High Very High Very High
Mycosis Fungoides 48 99.38 Very High Very High Very High
Necrosis 5 99.24 Very High Very High Very High
Apoptosis 85 98.80 Very High Very High Very High
Genetic Predisposition To Disease 1 98.68 Very High Very High Very High
Skin Diseases 1 96.64 Very High Very High Very High
Lymphatic System Cancer 146 94.56 High High
Cytomegalovirus Infection 1 86.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One involves the interaction of a death receptor such as the tumor necrosis factor receptor-1 (TNFR1) or the Fas receptor with its ligand and the second pathway depends on the participation of mitochondria.
death receptor Binding (interaction) of associated with necrosis, cancer and death
1) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 1.82 Pain Relevance 0
TRAIL acts through binding to its cognate receptors DR4 and/or DR5 [7]–[9].
DR5 Binding (binding) of
2) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2641005 Disease Relevance 0.74 Pain Relevance 0
That MF/SS patients have class II HLA associations with DR5 and DQB*03 alleles does support genetic predisposition similar to other autoimmune skin diseases (Jackow et al 1996).
DR5 Binding (associations) of in skin associated with mycosis fungoides, skin diseases, syndrome and genetic predisposition to disease
3) Confidence 0.04 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721288 Disease Relevance 1.47 Pain Relevance 0.10

General Comments

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