INT26112

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Context Info
Confidence 0.69
First Reported 1983
Last Reported 2006
Negated 0
Speculated 1
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 4.28
Pain Relevance 5.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Hrh2) signal transducer activity (Hrh2)
Anatomy Link Frequency
smooth muscles 1
parietal cell 1
brain 1
Hrh2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 21 100.00 Very High Very High Very High
Clonidine 4 99.72 Very High Very High Very High
antinociception 13 99.44 Very High Very High Very High
peptic ulcer disease 1 99.32 Very High Very High Very High
Perioperative pain 1 99.08 Very High Very High Very High
opioid receptor 1 98.94 Very High Very High Very High
Antinociceptive 6 98.12 Very High Very High Very High
Analgesic 7 97.88 Very High Very High Very High
agonist 9 95.12 Very High Very High Very High
guanethidine 2 93.84 High High
Disease Link Frequency Relevance Heat
Nociception 1 99.90 Very High Very High Very High
Gastroesophageal Reflux Disease 5 99.84 Very High Very High Very High
Ulcers 5 99.32 Very High Very High Very High
Hypotension 5 99.32 Very High Very High Very High
Post Operative Pain 1 99.08 Very High Very High Very High
Disease 3 98.80 Very High Very High Very High
Adenocarcinoma 9 98.72 Very High Very High Very High
Increased Venous Pressure Under Development 1 97.48 Very High Very High Very High
Duodenal Ulcer 1 97.44 Very High Very High Very High
Nicotine Addiction 17 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data do not support previous suggestions that the hypotensive action of clonidine is caused by stimulation of the H2-receptor, but suggest that central administration of cimetidine causes peripheral vasoconstriction and this may offer resistance to the hypotensive action of different antihypertensive agents.
Positive_regulation (stimulation) of H2-receptor associated with hypotension, increased venous pressure under development and clonidine
1) Confidence 0.69 Published 1985 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 2862255 Disease Relevance 0.80 Pain Relevance 0.43
It is suggested that the histaminergic system modulates nociception via activation of the H2-receptor.
Positive_regulation (activation) of H2-receptor associated with nociception
2) Confidence 0.58 Published 1996 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 8866956 Disease Relevance 0.16 Pain Relevance 0.38
Proton pump inhibitors appeared to be associated with a limited increase in fracture risk, in contrast to histamine H( 2 ) antagonists, which seemed to be associated with a small decrease in fracture risk.
Positive_regulation (increase) of histamine H associated with antagonist
3) Confidence 0.49 Published 2006 Journal Calcif. Tissue Int. Section Abstract Doc Link 16927047 Disease Relevance 0.30 Pain Relevance 0.29
These findings strongly suggest that stimulation of opioid receptors leads to antinociception by mechanisms that include activation of brain H2-receptors.
Positive_regulation (activation) of H2-receptor in brain associated with antinociception and opioid receptor
4) Confidence 0.49 Published 1989 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2547933 Disease Relevance 0.13 Pain Relevance 1.67
The data obtained clearly show that H2-receptor activation is involved in the mechanism of the Tyr-MIF-1 antinociceptive action.
Positive_regulation (activation) of H2-receptor associated with antinociceptive
5) Confidence 0.23 Published 2003 Journal Arch. Physiol. Biochem. Section Abstract Doc Link 16026032 Disease Relevance 0.09 Pain Relevance 0.59
At present, conclusions on H2-receptor mediation in LH release induced by histamine cannot be drawn from these results.
Positive_regulation (mediation) of H2-receptor
6) Confidence 0.14 Published 1983 Journal Exp Brain Res Section Abstract Doc Link 6139293 Disease Relevance 0 Pain Relevance 0.41
H2-receptor antagonists are generally less effective in GERD than in peptic ulcer disease.
Positive_regulation (effective) of H2-receptor associated with peptic ulcer disease, antagonist, gastroesophageal reflux disease and disease
7) Confidence 0.09 Published 1997 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 9305472 Disease Relevance 0.96 Pain Relevance 0.19
This increased gastric acid secretion is mediated through the stimulation of H2-receptor by histamine released after mast cell degranulation and due to the increase of the functional parietal cell volume or secretory capacity in smokers.
Positive_regulation (stimulation) of H2-receptor in parietal cell associated with nicotine addiction
8) Confidence 0.03 Published 2003 Journal Mol. Cell. Biochem. Section Abstract Doc Link 14619984 Disease Relevance 1.08 Pain Relevance 0.26
Stimulation of H1 or H2-receptor produces excitatory or inhibitory effects, respectively, on the smooth muscles and on the adrenergic nerves.
Positive_regulation (Stimulation) of H2-receptor in smooth muscles
9) Confidence 0.03 Published 1983 Journal Pflugers Arch. Section Abstract Doc Link 6647000 Disease Relevance 0 Pain Relevance 0.16
H2-receptor antagonists may increase the risk of cardio-oesophageal adenocarcinoma: a case-control study.
Spec (may) Positive_regulation (increase) of H2-receptor associated with adenocarcinoma and antagonist
10) Confidence 0.02 Published 2000 Journal Eur. J. Cancer Prev. Section Title Doc Link 10954258 Disease Relevance 0.53 Pain Relevance 0.17
Clinical evaluation of H1-receptor and H2-receptor antagonists for acute postoperative pain.
Positive_regulation (evaluation) of H2-receptor associated with antagonist and perioperative pain
11) Confidence 0.02 Published 1993 Journal J Clin Pharmacol Section Title Doc Link 8227466 Disease Relevance 0.24 Pain Relevance 0.99

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