INT261142

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 5.66
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

HPV18I1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 12 83.28 Quite High
addiction 8 61.60 Quite High
analgesia 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Papillomavirus Infection 492 100.00 Very High Very High Very High
Infection 300 99.96 Very High Very High Very High
Starvation 16 95.84 Very High Very High Very High
Cancer 40 91.88 High High
Wound Healing 4 36.60 Quite Low
Injury 4 13.24 Low Low
Influenza Virus Infection 32 5.00 Very Low Very Low Very Low
Cervical Cancer 8 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this context, our high throughput chemical biology screening approach that led to the current study on the role of cell cycle in HPV infection also has successfully identified many other compounds that inhibit HPV infection, and their initial evaluation points to promising lead compounds for further development as microbicides.
Negative_regulation (inhibit) of HPV associated with papillomavirus infection and infection
1) Confidence 0.01 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2642596 Disease Relevance 1.67 Pain Relevance 0.03
Nevertheless, due to limitations of recently approved HPV vaccines, including incomplete coverage of high-risk HPV genotypes and high cost, there is an urgent need to identify other approaches to prevent HPV infections.
Negative_regulation (prevent) of HPV associated with papillomavirus infection and infection
2) Confidence 0.01 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2642596 Disease Relevance 1.76 Pain Relevance 0.14
HaCaT cells incubated in serum free medium showed complete cell cycle arrest at G1 phase and dramatic inhibition of HPV infection (Figure 2A and 2B).
Negative_regulation (inhibition) of HPV associated with papillomavirus infection and infection
3) Confidence 0.01 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2642596 Disease Relevance 1.51 Pain Relevance 0
Among the confirmed hits identified in the primary screen were cell cycle inhibitors etoposide [12] and aphidicolin [13], which showed the most significant and consistent inhibition of HPV infection in 293 cells both using HPV16 pseudoviruses expressing SEAP or renilla luciferase reporter genes (data not shown), or using intact infectious HPV16 virus in which we scored for early gene expression (see Figure S1).
Negative_regulation (inhibition) of HPV associated with papillomavirus infection and infection
4) Confidence 0.01 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2642596 Disease Relevance 0.72 Pain Relevance 0

General Comments

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